148085 20250127144949.0 sideral 63782 ART-2009-63782 eng Aznar, M. Universidad de Zaragoza (orcid)0000-0002-0759-9170 Quantitative Determination of 22 Primary Aromatic Amines by Cation-Exchange Solid-Phase Extraction and Liquid Chromatography-Mass Spectrometry 2009 Access copy available to the general public Unrestricted Primary aromatic amines (PAAs) have been broadly studied due to their high toxicity. In this work a method for the analysis of 22 PAAs in aqueous simulants has been developed. The method is based on a solid-phase extraction step using cation-exchange cartridges and the subsequent analysis of the extracts by ultra-high-performance liquid chromatography with mass spectrometric detection. The recoveries obtained for all the amines analyzed ranged between 81 and 109%, linear range was between 0.03 and 75 μg L−1, with the RSD values between 4.5 and 13.4% and an average value of 7.5% and limits of detection at μg L−1 level. The method has been applied to two real samples obtained from migration experiments of polyurethane based laminates to simulant B (water with 3% (w/v) acetic acid) which represents the worst case for the migration of aromatic amines. The main amines found in both samples were methylenedianiline isomers, obtained from the corresponding residual diisocyanates used during polyurethane adhesive polymerization. The total amine concentration found was 26 and 6.3 μg of aniline equivalents per kg of food simulant. info:eu-repo/grantAgreement/ES/MEC/PET2006_0512_00 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.101 2009 CHEMISTRY, ANALYTICAL 4 / 70 = 0.057 2009 Q1 T1 BIOCHEMICAL RESEARCH METHODS 13 / 67 = 0.194 2009 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Canellas, E. Universidad de Zaragoza (orcid)0000-0003-2638-9221 Nerin, C. Universidad de Zaragoza (orcid)0000-0003-2685-5739 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 2009 X Universidad de Zaragoza Dpto. Química Analítica Proy. investigación HVA 1216, 27 (2009), 5176-5181 J. chromatogr. A Journal of Chromatography A 0021-9673 248583 http://zaguan.unizar.es/record/148085/files/texto_completo.pdf Postprint 1356435 http://zaguan.unizar.es/record/148085/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:148085 articulos driver 2025-01-27-14:45:28 ARTICLE