000148088 001__ 148088 000148088 005__ 20250114155432.0 000148088 0248_ $$2sideral$$a113307 000148088 037__ $$aART-2017-113307 000148088 041__ $$aeng 000148088 100__ $$0(orcid)0000-0001-6650-8294$$aMateo-Gallego, Rocio$$uUniversidad de Zaragoza 000148088 245__ $$aAdherence to a Mediterranean diet is associated with the presence and extension of atherosclerotic plaques in middle-aged asymptomatic adults: The Aragon Workers' Health Study 000148088 260__ $$c2017 000148088 5060_ $$aAccess copy available to the general public$$fUnrestricted 000148088 5203_ $$aBackground The Mediterranean diet (MeDi) is known to prevent cardiovascular events but the mechanisms mediating this association are not fully understood. Objective The objective of the study was to examine the association between MeDi adherence and the presence and extent of atherosclerotic plaques in carotid, femoral, and aorta territories and its relationship with risk factors in asymptomatic middle-aged adults. Methods Cross-sectional analysis of the Aragon Workers' Health Study, a cohort of 2588 subjects (94.9% men aged 51.3 ± 3.89 years) without previous cardiovascular history. Participants underwent carotid, femoral, and aorta ultrasound for the quantification of number and thickness of plaques and intima-media thickness. To estimate the participant's adherence to MeDi, we computed the Alternative MEDiterranean index (aMED). Results The overall aMED score was 4.19 ± 1.70, representing a moderate adherence to MeDi. aMED score was associated with the presence of plaque in femoral arteries (odds ratio highest vs lowest aMED score quartile: 0.63; 95% confidence interval: 0.48–0.83; P trend = .045) independently of risk factors and mediators. The strongest association between aMED quartiles and presence of plaque was found among smokers, both in femoral (0.39 [0.22–0.69]; P trend = .001) and in any territory (0.33 [0.14–0.79], P trend = .008). aMED was inversely associated with the number of plaques in all territories except for carotids. Conclusion MeDi adherence showed a dose-dependent protective association with the presence, number, and thickness of plaques independent of other risk factors. The association was strongest for femoral arteries and among smokers. 000148088 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/IIS16-0114$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PIE16-00022 000148088 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000148088 590__ $$a3.58$$b2017 000148088 591__ $$aPHARMACOLOGY & PHARMACY$$b61 / 260 = 0.235$$c2017$$dQ1$$eT1 000148088 592__ $$a1.654$$b2017 000148088 593__ $$aCardiology and Cardiovascular Medicine$$c2017$$dQ1 000148088 593__ $$aNutrition and Dietetics$$c2017$$dQ1 000148088 593__ $$aInternal Medicine$$c2017$$dQ1 000148088 593__ $$aEndocrinology, Diabetes and Metabolism$$c2017$$dQ1 000148088 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000148088 700__ $$aUzhova, Irina 000148088 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belen$$uUniversidad de Zaragoza 000148088 700__ $$aLeon-Latre, Montserrat$$uUniversidad de Zaragoza 000148088 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, Jose A.$$uUniversidad de Zaragoza 000148088 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martin 000148088 700__ $$aPenalvo, Jose L. 000148088 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza 000148088 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000148088 7102_ $$11008$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Med.Pr.,Sal.Públ.$$cÁrea Medic.Prevent.Salud Públ. 000148088 773__ $$g11, 6 (2017), 1372 - 1382$$pJournal of Clinical Lipidology$$tJournal of Clinical Lipidology$$x1933-2874 000148088 8564_ $$s625158$$uhttps://zaguan.unizar.es/record/148088/files/texto_completo.pdf$$yPostprint 000148088 8564_ $$s2205038$$uhttps://zaguan.unizar.es/record/148088/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000148088 909CO $$ooai:zaguan.unizar.es:148088$$particulos$$pdriver 000148088 951__ $$a2025-01-13-14:27:31 000148088 980__ $$aARTICLE