148091 20250114155432.0 doi 10.1111/add.15012 sideral 118495 ART-2020-118495 eng Moreno-Franco, Belén Universidad de Zaragoza (orcid)0000-0003-0604-5042 Association between alcohol consumption and subclinical femoral atherosclerosis in smoking and non-smoking men: The AWHS Study 2020 Background and Aims: Many addictive substances, such as tobacco and alcohol, influence atherosclerosis development. Whether or not tobacco's pro-atherosclerotic effect is influenced by alcohol consumption is unknown. We aimed to estimate the impact of alcohol intake on the presence of subclinical atherosclerosis in femoral arteries in smoking and non-smoking middle-aged men.Design, Setting and Participants: Cross-sectional analysis of a subset of the Aragon Workers Health Study (AWHS), comprising 2099 men with mean age 50.9 years without previous cardiovascular disease. Measurements: The presence of plaques in femoral arteries was assessed by high-resolution sonography. Self-reported alcohol consumption over the previous year was measured with a food frequency questionnaire. The sample was divided into four groups according to their daily grams of alcohol consumption = 1 (abstainers), = 2 to < 30, = 30 to < 60 and = 60 g/day. Participants were divided on ever-smoking (current and former) versus never-smoking strata in the main analysis. Findings: We did not find a significant association between the different levels of alcohol intake and the likelihood of developing femoral artery atherosclerosis in never-smokers. Ever-smoking was positively associated with femoral atherosclerosis overall [odds ratio (OR) = 3.00; 95% confidence interval (CI) = 2.40, 3.74; P < 0.001] and within each level of alcohol consumption. Atherosclerosis was lower in ever-smokers who consumed 2 g/day or more but less than 30 g/day with respect to those ever-smokers who were abstainers (OR = 0.70; 95% CI = 0.49, 0.99; P < 0.05). However, among these ever-smokers, atherosclerosis prevalence was still higher than among never-smokers who consumed alcohol in the same amount (2 g/day or more but less than 30 g/day) (OR = 2.73; 95% CI = 2.07, 3.61; P < 0.001). Conclusions: Among middle-aged men, moderate alcohol consumption appears to be associated with lower prevalence of femoral artery subclinical atherosclerosis compared with alcohol abstinence only in ever-smokers. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI17-10704 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI18-01929 info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 6.526 2020 PSYCHIATRY 21 / 155 = 0.135 2020 Q1 T1 SUBSTANCE ABUSE 3 / 37 = 0.081 2020 Q1 T1 PSYCHIATRY 14 / 142 = 0.099 2020 Q1 T1 SUBSTANCE ABUSE 2 / 21 = 0.095 2020 Q1 T1 2.423 2020 Psychiatry and Mental Health 2020 Q1 Medicine (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Pérez-Esteban, Alejandro Civeira, Fernando Universidad de Zaragoza (orcid)0000-0001-7043-0952 Guallar-Castillón, Pilar Casasnovas, José Antonio Universidad de Zaragoza (orcid)0000-0002-9887-2629 Mateo-Gállego, Rocío Universidad de Zaragoza (orcid)0000-0001-6650-8294 Jarauta, Estíbaliz Universidad de Zaragoza (orcid)0000-0001-9142-0737 Malo, Sara Universidad de Zaragoza (orcid)0000-0002-7194-8275 Laclaustra, Martín Universidad de Zaragoza (orcid)0000-0003-3963-0846 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 115, 9 (2020), 1754-1761 Addiction ADDICTION 0965-2140 1062466 http://zaguan.unizar.es/record/148091/files/texto_completo.pdf Postprint 997861 http://zaguan.unizar.es/record/148091/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:148091 articulos driver 2025-01-13-14:27:34 ARTICLE