000148097 001__ 148097
000148097 005__ 20250114155432.0
000148097 0247_ $$2doi$$a10.3390/nu13093134
000148097 0248_ $$2sideral$$a125823
000148097 037__ $$aART-2021-125823
000148097 041__ $$aeng
000148097 100__ $$0(orcid)0000-0002-1275-2600$$aSantander Ballestín S.$$uUniversidad de Zaragoza
000148097 245__ $$aIs supplementation with micronutrients still necessary during pregnancy? A review
000148097 260__ $$c2021
000148097 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148097 5203_ $$aIntroduction: Proper nutrition during pregnancy is important to prevent nutritional imbalances that interfere with pregnancy. Micronutrients play critical roles in embryogenesis, fetal growth, and maternal health, as energy, protein, vitamin, and mineral needs can increase during pregnancy. Increased needs can be met by increasing the intake of dietary micronutrients. Severe micronutrient deficiency or excess during pregnancy can have negative effects on fetal growth (intrauterine growth retardation, low birth weight, or congenital malformations) and pregnancy development (pre-eclampsia or gestational diabetes). We investigate whether it is necessary to continue micronutrient supplementation during pregnancy to improve women’s health in this stage and whether this supplementation could prevent and control pathologies associated with pregnancy. Aim: The present review aims to summarize evidence on the effects of nutritional deficiencies on maternal and newborn morbidity. Methods: This aim is addressed by critically reviewing results from published studies on supplementation with different nutrients during pregnancy. For this, major scientific databases, scientific texts, and official webpages have been consulted. PubMed searches using the terms “pregnancy” OR “maternal-fetal health” AND “vitamins” OR “minerals” OR “supplementation” AND “requirement” OR “deficiency nutrients” were performed. Results: There are accepted interventions during pregnancy, such as folic acid supplementation to prevent congenital neural tube defects, potassium iodide supplementation to correct neurodevelopment, and oral iron supplementation during the second half of pregnancy to reduce the risk of maternal anemia and iron deficiency. A number of micronutrients have also been associated with pre-eclampsia, gestational diabetes mellitus, and nausea and vomiting in pregnancy. In general, experimental studies are necessary to demonstrate the benefits of supplementation with different micronutrients and to adjust the recommended daily doses and the recommended periconceptional nutrition for mothers. Conclusions: Presently, there is evidence of the benefits of micronutrient supplementation in perinatal results, but indiscriminate use is discouraged due to the fact that the side effects of excessive doses are not known. Evidence supports the idea that micronutrient deficiencies negatively affect maternal health and the outcome of pregnancy. No single micronutrient is responsible for the adverse effects; thus, supplementing or correcting one deficiency will not be very effective while other deficiencies exist. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
000148097 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000148097 590__ $$a6.706$$b2021
000148097 591__ $$aNUTRITION & DIETETICS$$b15 / 90 = 0.167$$c2021$$dQ1$$eT1
000148097 592__ $$a1.287$$b2021
000148097 593__ $$aNutrition and Dietetics$$c2021$$dQ1
000148097 593__ $$aFood Science$$c2021$$dQ1
000148097 594__ $$a7.9$$b2021
000148097 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148097 700__ $$aGimenez Campos M.I.
000148097 700__ $$aBallestín Ballestín J.
000148097 700__ $$0(orcid)0000-0003-4071-1467$$aLuesma Bartolomé M.J.$$uUniversidad de Zaragoza
000148097 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000148097 7102_ $$11012$$2315$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Farmacología
000148097 773__ $$g13, 9 (2021), 13093134[30 pp.]$$pNutrients$$tNutrients$$x2072-6643
000148097 8564_ $$s10772512$$uhttps://zaguan.unizar.es/record/148097/files/texto_completo.pdf$$yVersión publicada
000148097 8564_ $$s2715643$$uhttps://zaguan.unizar.es/record/148097/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148097 909CO $$ooai:zaguan.unizar.es:148097$$particulos$$pdriver
000148097 951__ $$a2025-01-13-14:27:46
000148097 980__ $$aARTICLE