148107 20250114155432.0 doi 10.3390/jcm10081568 sideral 125983 ART-2021-125983 eng Santander Ballestín, Sonia Universidad de Zaragoza (orcid)0000-0002-1275-2600 Hepatitis C: A Pharmacological Therapeutic Update 2021 (1) Background: Hepatitis C is a high-prevalence disease, representing a global impact health problem. Lately, many changes have been made in treatment guidelines because of the commercialization of second-generation direct-acting antivirals due to their high effectiveness, few side effects and pangenotypic action. We address the pharmacological possibilities available and compare them with the current recommendations of the World Health Organization (WHO). (2) Methods: The search for articles was made through the PubMed database using different search strategies and we consulted technical data sheets of the treatments that have been included in the study. (3) Results: Combinations of “glecaprevir/pibrentasvir”, “sofosbuvir/velpatasvir” and “sofosbuvir/velpatasvir/voxilaprevir” have been recently incorporated. Phase II studies have shown that they are safe and effective therapies with very comfortable posologies and easy therapeutic adherence; furthermore, they suppose shorter treatment duration. Subsequently, phase III studies have shown they were effective for previously treated or compensated cirrhotic patients that previously had more complex treatment regimens. (4) Conclusions: These results suppose a simplification in Hepatitis C therapeutic approach, and open new study possibilities. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.964 2021 MEDICINE, GENERAL & INTERNAL 55 / 172 = 0.32 2021 Q2 T1 1.04 2021 Medicine (miscellaneous) 2021 Q1 4.4 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gómez Martín, David Lorente Pérez, Sara Universidad de Zaragoza (orcid)0000-0003-4672-8083 Luesma Bartolomé, María José Universidad de Zaragoza (orcid)0000-0003-4071-1467 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1012 315 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Farmacología 10, 8 (2021), 1568 J. clin.med. Journal of Clinical Medicine 2077-0383 1939151 http://zaguan.unizar.es/record/148107/files/texto_completo.pdf Versión publicada 2731440 http://zaguan.unizar.es/record/148107/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:148107 articulos driver 2025-01-13-14:27:56 ARTICLE