000148115 001__ 148115
000148115 005__ 20250214141228.0
000148115 0247_ $$2doi$$a10.1016/j.atherosclerosis.2024.118617
000148115 0248_ $$2sideral$$a141580
000148115 037__ $$aART-2025-141580
000148115 041__ $$aeng
000148115 100__ $$aBea, Ana M.
000148115 245__ $$aAssociation of HDL cholesterol with all-cause and cardiovascular mortality in primary hypercholesterolemia
000148115 260__ $$c2025
000148115 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148115 5203_ $$aBackground and aims. Recent reports have shown that subjects with high high-density lipoprotein cholesterol (HDLc) levels are paradoxically at increased risk for all-cause and cardiovascular mortality. The aim was to study the association of HDLc concentration with mortality in subjects with high cholesterol.
Methods. We analyzed total mortality, cardiovascular mortality, and non-cardiovascular mortality in a cohort of 2992 subjects with primary hypercholesterolemia, who were followed for 10.2 years (range 1–25 years), with a total of 30,602 subject-years of follow-up.
Results. During follow-up, 168 subjects died, with 52 (13.7 %), 105 (4.80 %), and 11 (2.60 %) in the low, normal, and high HDLc groups, respectively (p < 0.001). The risk of death was 2.89 times higher (95 % confidence interval (CI), 1.50–5.57, p < 0.001) in subjects in the low HDLc group compared to those in the high HDLc group and 1.48 times higher (95 % CI 0.80–2.76, p = 0.214) in the normal HDLc group compared to the high HDLc group. However, HDLc concentration and HDLc groups based on HDLc concentration were not independently associated with mortality in Cox regression analysis. Cardiovascular and non-cardiovascular mortalities showed similar results.
Conclusions. All types of mortality were lower in subjects with primary hypercholesterolemia and with high HDLc in univariate analysis. Elevated HDLc was not associated with total, cardiovascular, and non-cardiovascular mortality when adjusted for major cardiovascular risk factors.
000148115 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI19-00694$$9info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI22-01595$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/CIBERCV
000148115 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000148115 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148115 700__ $$aGonzález-Guerrero, Anton
000148115 700__ $$aCenarro, Ana
000148115 700__ $$0(orcid)0000-0002-9647-0108$$aLamiquiz-Moneo, Itziar$$uUniversidad de Zaragoza
000148115 700__ $$aCliment, Elisenda
000148115 700__ $$0(orcid)0000-0001-9142-0737$$aJarauta, Estibaliz$$uUniversidad de Zaragoza
000148115 700__ $$aGracia-Rubio, Irene$$uUniversidad de Zaragoza
000148115 700__ $$aBenaiges, David
000148115 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza
000148115 700__ $$0(orcid)0000-0001-5026-5144$$aTejedor, Teresa$$uUniversidad de Zaragoza
000148115 700__ $$aPedro-Botet, Juan
000148115 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza
000148115 700__ $$aMarco-Benedí, Victoria$$uUniversidad de Zaragoza
000148115 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000148115 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000148115 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148115 773__ $$g400 (2025), 118617 [9 pp.]$$pAtherosclerosis$$tAtherosclerosis$$x0021-9150
000148115 8564_ $$s4754457$$uhttps://zaguan.unizar.es/record/148115/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2025-09-26
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000148115 909CO $$ooai:zaguan.unizar.es:148115$$particulos$$pdriver
000148115 951__ $$a2025-02-14-14:11:23
000148115 980__ $$aARTICLE