148115 20250928074251.0 4754457 http://zaguan.unizar.es/record/148115/files/texto_completo.pdf Postprint info:eu-repo/date/embargoEnd/2025-09-26 1234507 http://zaguan.unizar.es/record/148115/files/texto_completo.jpg?subformat=icon icon Postprint info:eu-repo/date/embargoEnd/2025-09-26 400 (2025), 118617 [9 pp.] Atherosclerosis Atherosclerosis 0021-9150 info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI19-00694 info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI22-01595 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/CIBERCV 2025-05-20-10:14:05 ARTICLE oai:zaguan.unizar.es:148115 articulos driver González-Guerrero, Anton Cenarro, Ana (orcid)0000-0002-9647-0108 Lamiquiz-Moneo, Itziar Universidad de Zaragoza Climent, Elisenda (orcid)0000-0001-9142-0737 Jarauta, Estibaliz Universidad de Zaragoza (orcid)0000-0003-1028-8581 Gracia-Rubio, Irene Universidad de Zaragoza Benaiges, David (orcid)0000-0003-3963-0846 Laclaustra, Martín Universidad de Zaragoza (orcid)0000-0001-5026-5144 Tejedor, Teresa Universidad de Zaragoza Pedro-Botet, Juan (orcid)0000-0001-7043-0952 Civeira, Fernando Universidad de Zaragoza Marco-Benedí, Victoria Universidad de Zaragoza info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina Association of HDL cholesterol with all-cause and cardiovascular mortality in primary hypercholesterolemia doi 10.1016/j.atherosclerosis.2024.118617 sideral 141580 2025 Background and aims. Recent reports have shown that subjects with high high-density lipoprotein cholesterol (HDLc) levels are paradoxically at increased risk for all-cause and cardiovascular mortality. The aim was to study the association of HDLc concentration with mortality in subjects with high cholesterol. Methods. We analyzed total mortality, cardiovascular mortality, and non-cardiovascular mortality in a cohort of 2992 subjects with primary hypercholesterolemia, who were followed for 10.2 years (range 1–25 years), with a total of 30,602 subject-years of follow-up. Results. During follow-up, 168 subjects died, with 52 (13.7 %), 105 (4.80 %), and 11 (2.60 %) in the low, normal, and high HDLc groups, respectively (p < 0.001). The risk of death was 2.89 times higher (95 % confidence interval (CI), 1.50–5.57, p < 0.001) in subjects in the low HDLc group compared to those in the high HDLc group and 1.48 times higher (95 % CI 0.80–2.76, p = 0.214) in the normal HDLc group compared to the high HDLc group. However, HDLc concentration and HDLc groups based on HDLc concentration were not independently associated with mortality in Cox regression analysis. Cardiovascular and non-cardiovascular mortalities showed similar results. Conclusions. All types of mortality were lower in subjects with primary hypercholesterolemia and with high HDLc in univariate analysis. Elevated HDLc was not associated with total, cardiovascular, and non-cardiovascular mortality when adjusted for major cardiovascular risk factors. Access copy available to the general public Unrestricted info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Bea, Ana M. ART-2025-141580 eng