000148127 001__ 148127
000148127 005__ 20250114155432.0
000148127 0247_ $$2doi$$a10.1016/j.jacc.2017.09.032
000148127 0248_ $$2sideral$$a141656
000148127 037__ $$aART-2017-141656
000148127 041__ $$aeng
000148127 100__ $$aFernández-Alvira, Juan Miguel
000148127 245__ $$aPredicting subclinical atherosclerosis in low-risk individuals
000148127 260__ $$c2017
000148127 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148127 5203_ $$aBackground:
The ideal cardiovascular health score (ICHS) is recommended for use in primary prevention. Simpler tools not requiring laboratory tests, such as the Fuster-BEWAT (blood pressure [B], exercise [E], weight [W], alimentation [A], and tobacco [T]) score (FBS), are also available.
Objectives:
The purpose of this study was to compare the effectiveness of ICHS and FBS in predicting the presence and extent of subclinical atherosclerosis.
Methods:
A total of 3,983 participants 40 to 54 years of age were enrolled in the PESA (Progression of Early Subclinical Atherosclerosis) cohort. Subclinical atherosclerosis was measured in right and left carotids, abdominal aorta, right and left iliofemoral arteries, and coronary arteries. Subjects were classified as having poor, intermediate, or ideal cardiovascular health based on the number of favorable ICHS or FBS.
Results:
With poor ICHS and FBS as references, individuals with ideal ICHS and FBS showed lower adjusted odds of having atherosclerotic plaques (ICHS odds ratio [OR]: 0.41; 95% confidence interval [CI]: 0.31 to 0.55 vs. FBS OR: 0.49; 95% CI: 0.36 to 0.66), coronary artery calcium (CACS) ≥1 (CACS OR: 0.41; 95% CI: 0.28 to 0.60 vs. CACS OR: 0.53; 95% CI: 0.38 to 0.74), higher number of affected territories (OR: 0.32; 95% CI: 0.26 to 0.41 vs. OR: 0.39; 95% CI: 0.31 to 0.50), and higher CACS level (OR: 0.40; 95% CI: 0.28 to 0.58 vs. OR: 0.52; 95% CI: 0.38 to 0.72). Similar levels of significantly discriminating accuracy were found for ICHS and FBS with respect to the presence of plaques (C-statistic: 0.694; 95% CI: 0.678 to 0.711 vs. 0.692; 95% CI: 0.676 to 0.709, respectively) and for CACS ≥1 (C-statistic: 0.782; 95% CI: 0.765 to 0.800 vs. 0.780; 95% CI: 0.762 to 0.798, respectively).
Conclusions:
Both scores predict the presence and extent of subclinical atherosclerosis with similar accuracy, highlighting the value of the FBS as a simpler and more affordable score for evaluating the risk of subclinical disease.
000148127 536__ $$9info:eu-repo/grantAgreement/EC/H2020/707642/EU/Comprehensive Lifestyle Intervention Project (CLIP)/CLIP$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 707642-CLIP
000148127 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000148127 590__ $$a16.834$$b2017
000148127 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b3 / 128 = 0.023$$c2017$$dQ1$$eT1
000148127 592__ $$a11.061$$b2017
000148127 593__ $$aCardiology and Cardiovascular Medicine$$c2017$$dQ1
000148127 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148127 700__ $$aFuster, Valentín
000148127 700__ $$aPocock, Stuart
000148127 700__ $$aSanz, Javier
000148127 700__ $$aFernández-Friera, Leticia
000148127 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín
000148127 700__ $$aFernández-Jiménez, Rodrigo
000148127 700__ $$aMendiguren, José
000148127 700__ $$aFernández-Ortiz, Antonio
000148127 700__ $$aIbáñez, Borja
000148127 700__ $$aBueno, Héctor
000148127 773__ $$g70, 20 (2017), 2463-2473$$pJ. Am. Coll. Cardiol.$$tJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY$$x0735-1097
000148127 8564_ $$s558241$$uhttps://zaguan.unizar.es/record/148127/files/texto_completo.pdf$$yVersión publicada
000148127 8564_ $$s2158169$$uhttps://zaguan.unizar.es/record/148127/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148127 909CO $$ooai:zaguan.unizar.es:148127$$particulos$$pdriver
000148127 951__ $$a2025-01-14-15:52:02
000148127 980__ $$aARTICLE