000148168 001__ 148168
000148168 005__ 20250114175434.0
000148168 0247_ $$2doi$$a10.3390/jcm14020411
000148168 0248_ $$2sideral$$a141636
000148168 037__ $$aART-2025-141636
000148168 041__ $$aeng
000148168 100__ $$0(orcid)0000-0001-6351-0444$$aRodríguez-Sanz, Jorge
000148168 245__ $$aPeripheral extracellular vesicles for diagnosis and prognosis of resectable lung cancer: the LUCEx study protocol
000148168 260__ $$c2025
000148168 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148168 5203_ $$aBackground/Objectives: Lung cancer is the primary cause of cancer-related deaths. Most patients are typically diagnosed at advanced stages. Low-dose computed tomography (LDCT) has been proven to reduce lung cancer mortality, but screening programs using LDCT are associated with a high number of false positives and unnecessary thoracotomies. It is therefore imperative that a certain diagnosis is refined, especially in cases of solitary pulmonary nodules that are difficult to technically access for an accurate preoperative diagnosis. Extracellular vesicles (EVs) involved in intercellular communication may be an innovative biomarker for diagnosis and therapeutic strategies in lung cancer, regarding their ability to carry tumor-specific cargo. The aim of the LUCEx study is to determine if extracellular vesicle cargoes from both lung tissue and blood could provide complementary information to screen lung cancer patients and enable personalized follow-up after the surgery. Methods: The LUCEx study is a prospective study aiming to recruit 600 patients with lung cancer and 50 control subjects (false positives) undergoing surgery after diagnostic imaging for suspected pulmonary nodules using computed tomography (CT) scans. These patients will undergo curative surgery at the Department of Thoracic Surgery of the Miguel Servet Hospital in Zaragoza, Spain, and will be followed-up for at least 5 years. At baseline, samples from both tumor distal lung tissue and preoperative peripheral blood will be collected and processed to compare the quantity and content of EVs, particularly their micro-RNA (miRNA) cargo. At the third and fifth years of follow-up, CT scans, functional respiratory tests, and blood extractions will be performed. Discussion: Extracellular vesicles and their miRNA have emerged as promising tools for the diagnosis and prognosis of several diseases, including cancer. The LUCEx study, based on an observational clinical cohort, aims to understand the role of these vesicles and their translational potential as complementary tools for imaging diagnosis and prognosis.
000148168 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B22-23R$$9info:eu-repo/grantAgreement/ES/DGA-CUS/1638-2022$$9info:eu-repo/grantAgreement/ES/IISAragón/FSE-I-01/Intramural23$$9info:eu-repo/grantAgreement/ES/ISCIII CD22-00033$$9info:eu-repo/grantAgreement/ES/ISCIII/MV23-00010
000148168 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000148168 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148168 700__ $$0(orcid)0000-0002-3497-3236$$aMuñoz-González, Nadia
000148168 700__ $$aCubero, José Pablo
000148168 700__ $$aOrdoñez, Pablo
000148168 700__ $$aGil, Victoria
000148168 700__ $$aLangarita, Raquel
000148168 700__ $$aRuiz, Myriam
000148168 700__ $$aForner, Marta
000148168 700__ $$aMarín-Oto, Marta$$uUniversidad de Zaragoza
000148168 700__ $$aVera, Elisabet$$uUniversidad de Zaragoza
000148168 700__ $$0(orcid)0000-0002-8969-7726$$aBaptista, Pedro
000148168 700__ $$aPolverino, Francesca
000148168 700__ $$aDomingo, Juan Antonio$$uUniversidad de Zaragoza
000148168 700__ $$0(orcid)0000-0002-8976-6787$$aGarcía-Tirado, Javier$$uUniversidad de Zaragoza
000148168 700__ $$aMarin, José María
000148168 700__ $$0(orcid)0000-0002-5228-248X$$aSanz-Rubio, David
000148168 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148168 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000148168 773__ $$g14, 2 (2025), 411 [14 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000148168 8564_ $$s752494$$uhttps://zaguan.unizar.es/record/148168/files/texto_completo.pdf$$yVersión publicada
000148168 8564_ $$s2682537$$uhttps://zaguan.unizar.es/record/148168/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000148168 951__ $$a2025-01-14-15:48:42
000148168 980__ $$aARTICLE