The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium

Salazar, Henry Montero ; de Deus Mendonça, Raquel ; Laclaustra, Martín (Universidad de Zaragoza) ; Moreno-Franco, Belén ; Åkesson, Agneta ; Guallar-Castillón, Pilar ; Donat-Vargas, Carolina

Resumen: Purpose
It is suggested that polyphenols back the cardiovascular protection offered by the Mediterranean diet. This study evaluates the association of specific types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged subjects.
MethodsUltrasonography and TC were performed on 2318 men from the Aragon Workers Health Study, recruited between 2011 and 2014, to assess the presence of plaques in carotid and femoral arteries and coronary calcium. Polyphenol intake was assessed using a validated semi-quantitative 136-item food frequency questionnaire. The Phenol Explorer database was used to derive polyphenol class intake. Logistic and linear regressions were used to estimate the cross-sectional association of polyphenols intake with femoral and carotid subclinical atherosclerosis and coronary calcium.
Results
A higher intake of flavonoids (third vs. first tertile) was associated with a lower risk of both carotid (OR 0.80: CI 95% 0.62–1.02; P trend 0.094) and femoral (0.62: 0.48–0.80, P trend < 0.001) subclinical atherosclerosis. A higher intake of stilbenes was associated with a lower risk of femoral subclinical atherosclerosis (0.62: 0.46–0.83; P trend 0.009) and positive coronary calcium (0.75: 0.55–1.03; P trend 0.131). A higher intake of tyrosols was also associated with a lower risk of positive coronary calcium (0.80: 0.62–1.03; P trend 0.111). The associations remained similar when adjusted for blood lipids and blood pressure.
Conclusion
Dietary flavonoids, stilbenes, and tyrosols, whose main sources are red wine and virgin olive oil, are associated with lower prevalence of subclinical atherosclerosis in middle-aged subjects.

Idioma: Inglés

DOI: 10.1007/s00394-022-02823-0

Año: 2022

Publicado en: EUROPEAN JOURNAL OF NUTRITION 61, 5 (2022), 2697-2709
ISSN: 1436-6207

Factor impacto JCR: 5.0 (2022)

Categ. JCR: NUTRITION & DIETETICS rank: 28 / 87 = 0.322 (2022) - Q2 - T1

Factor impacto CITESCORE: 9.7 - Nursing (Q1) - Medicine (Q1)

Factor impacto SCIMAGO: 1.094 - Nutrition and Dietetics (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PIE16-00022
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI17-1709
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI20/144

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)