000148209 001__ 148209
000148209 005__ 20250114175435.0
000148209 0247_ $$2doi$$a10.1186/s12916-020-01678-8
000148209 0248_ $$2sideral$$a141664
000148209 037__ $$aART-2020-141664
000148209 041__ $$aeng
000148209 100__ $$aMontero-Salazar, Henry
000148209 245__ $$aHigh consumption of ultra-processed food may double the risk of subclinical coronary atherosclerosis: the Aragon Workers’ Health Study (AWHS)
000148209 260__ $$c2020
000148209 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148209 5203_ $$aUltra-processed food (UPF) consumption, which is increasing worldwide, has recently been associated with an increased risk of death and cardiovascular disease. We aimed to assess whether consumption of UPF is directly associated with subclinical coronary atherosclerosis in middle-aged men.MethodsA computed tomography scan was performed on 1876 men from the Aragon Workers’ Health Study, recruited from January 2011 to December 2014, to assess coronary calcium. All participants were free of coronary heart disease. Dietary intake was collected by a validated 136-item semi-quantitative food frequency questionnaire. UPF was defined according to the NOVA classification. Associations between consumption of total energy-adjusted UPF and Coronary Calcium Agatston Score (CACS)—categorized into CACS of 0, > 0 and < 100, and ≥ 100—were cross-sectionally assessed by generalized ordered logistic regression adjusted for main confounders.ResultsNo coronary calcium was detected in 60.2% of the participants, whereas 10.2% had a CACS ≥ 100. A significant dose-response association was observed between energy-adjusted UPF consumption and the risk of having a CACS ≥ 100, when compared with those in the lowest CACS categories (CACS of 0 together with CACS > 0 and < 100). The fully adjusted ORs (95% CI) of having a CACS ≥ 100 across quartiles of energy-adjusted UPF consumption (approximately 100 g/day in the lowest quartile (ref.) and 500 g/day in the highest) were 1.00 (ref.), 1.50 (0.93, 2.42), 1.56 (0.96, 2.52), and 2.00 (1.26, 3.16),ptrend .005.ConclusionIn this middle-aged worker’s sample, approximately 500 g/day of UPF consumption was associated with a 2-fold greater prevalence of subclinical coronary atherosclerosis than consuming only 100 g/day, independently of total energy intake and other well-established cardiovascular risk factors.
000148209 536__ $$9info:eu-repo/grantAgreement/EC/H2020/635316/EU/Ageing Trajectories of Health: Longitudinal Opportunities and Synergies/ATHLOS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 635316-ATHLOS$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PIE16-00022$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-01709
000148209 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000148209 590__ $$a8.775$$b2020
000148209 591__ $$aMEDICINE, GENERAL & INTERNAL$$b13 / 167 = 0.078$$c2020$$dQ1$$eT1
000148209 592__ $$a3.463$$b2020
000148209 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000148209 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148209 700__ $$aDonat-Vargas, Carolina
000148209 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza
000148209 700__ $$aSandoval-Insausti, Helena
000148209 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, Fernando$$uUniversidad de Zaragoza
000148209 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, Martín$$uUniversidad de Zaragoza
000148209 700__ $$aGuallar-Castillón, Pilar
000148209 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148209 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000148209 773__ $$g18, 1 (2020), 235 [11 pp.]$$pBMC Medicine$$tBMC Medicine$$x1741-7015
000148209 8564_ $$s945172$$uhttps://zaguan.unizar.es/record/148209/files/texto_completo.pdf$$yVersión publicada
000148209 8564_ $$s2204996$$uhttps://zaguan.unizar.es/record/148209/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148209 909CO $$ooai:zaguan.unizar.es:148209$$particulos$$pdriver
000148209 951__ $$a2025-01-14-15:49:31
000148209 980__ $$aARTICLE