000148218 001__ 148218 000148218 005__ 20250411150809.0 000148218 0247_ $$2doi$$a10.1093/sleep/zsae282 000148218 0248_ $$2sideral$$a141484 000148218 037__ $$aART-2024-141484 000148218 041__ $$aeng 000148218 100__ $$aHietakoste, Salla 000148218 245__ $$aNocturnal short-term heart rate variability reflects impaired daytime vigilance better than overnight heart rate variability in suspected obstructive sleep apnea patients 000148218 260__ $$c2024 000148218 5060_ $$aAccess copy available to the general public$$fUnrestricted 000148218 5203_ $$aIn obstructive sleep apnea (OSA), heart rate variability (HRV) decreases and performance in psychomotor vigilance task (PVT) worsens with more severe hypoxic load. Nevertheless, the association between HRV and PVT performance is poorly understood. Thus, we hypothesize that nocturnal short-term HRV is better related to daytime psychomotor vigilance compared with overnight HRV. To investigate this hypothesis, we retrospectively analyzed the electrocardiograms from polysomnographies of 546 consecutive patients with suspected OSA. We determined overnight HRV and short-term HRV in nonoverlapping 5-min segments and performed stepwise linear regression analyses to associate HRV with the median reaction time (RT) in the PVT. The short-term decrease in the median interval between two successive normal R peaks (NN interval), root mean square of successive NNs, and normalized high-frequency band power were all significant (p < 0.001) indicators of longer median RTs. However, the overnight HRV parameters did not indicate worsening median RT. Instead, increased hypoxic load and N3 duration were associated with longer median RT in men but not in women. The association of HRV and cardiorespiratory coupling with PVT performance was generally weak. Nocturnal short-term HRV evaluation reflected a state of vigilance better than the average overnight HRV. Thus, the overnight HRV analysis might not be optimal for patients with OSA. Utilizing the HRV analysis in a time-series manner and combined with the hypoxic load and sleep stages could bring new aspects to the health assessment of patients with OSA. 000148218 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T39-23R$$9info:eu-repo/grantAgreement/EC/H2020/965417/EU/Revolution of sleep diagnostics and personalized health care based on digital diagnostics and therapeutics with health data integration/SLEEP REVOLUTION$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 965417-SLEEP REVOLUTION$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-126734OB-C21$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-131106B-I00 000148218 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000148218 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000148218 700__ $$aKarhu, Tuomas 000148218 700__ $$aLombardi, Carolina 000148218 700__ $$0(orcid)0000-0001-5918-1043$$aArmañac-Julián, Pablo$$uUniversidad de Zaragoza 000148218 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, Raquel$$uUniversidad de Zaragoza 000148218 700__ $$aDuce, Brett 000148218 700__ $$aSillanmäki, Saara 000148218 700__ $$aTöyräs, Juha 000148218 700__ $$aLeppänen, Timo 000148218 700__ $$aMyllymaa, Sami 000148218 700__ $$aKainulainen, Samu 000148218 7102_ $$15007$$2520$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Ingen.Sistemas y Automát. 000148218 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac. 000148218 773__ $$g48, 4 (2024), [12 pp.]$$pSleep (N.Y. N.Y.)$$tSleep$$x0161-8105 000148218 8564_ $$s1824937$$uhttps://zaguan.unizar.es/record/148218/files/texto_completo.pdf$$yVersión publicada 000148218 8564_ $$s2435445$$uhttps://zaguan.unizar.es/record/148218/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000148218 909CO $$ooai:zaguan.unizar.es:148218$$particulos$$pdriver 000148218 951__ $$a2025-04-11-15:05:16 000148218 980__ $$aARTICLE