000148228 001__ 148228
000148228 005__ 20250115151521.0
000148228 0247_ $$2doi$$a10.1016/j.jconrel.2018.05.016
000148228 0248_ $$2sideral$$a135578
000148228 037__ $$aART-2018-135578
000148228 041__ $$aeng
000148228 100__ $$aGurruchaga, H
000148228 245__ $$aAdvances in the slow freezing cryopreservation of microencapsulated cells
000148228 260__ $$c2018
000148228 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148228 5203_ $$aOver the past few decades, the use of cell microencapsulation technology has been promoted for a wide range of applications as sustained drug delivery systems or as cells containing biosystems for regenerative medicine. However, difficulty in their preservation and storage has limited their availability to healthcare centers. Because the preservation in cryogenic temperatures poses many biological and biophysical challenges and that the technology has not been well understood, the slow cooling cryopreservation, which is the most used technique worldwide, has not given full measure of its full potential application yet. This review will discuss the different steps that should be understood and taken into account to preserve microencapsulated cells by slow freezing in a successful and simple manner. Moreover, it will review the slow freezing preservation of alginate-based microencapsulated cells and discuss some recommendations that the research community may pursue to optimize the preservation of microencapsulated cells, enabling the therapy translate from bench to the clinic.
000148228 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000148228 590__ $$a7.901$$b2018
000148228 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b22 / 172 = 0.128$$c2018$$dQ1$$eT1
000148228 591__ $$aPHARMACOLOGY & PHARMACY$$b9 / 266 = 0.034$$c2018$$dQ1$$eT1
000148228 592__ $$a2.411$$b2018
000148228 593__ $$aPharmaceutical Science$$c2018$$dQ1
000148228 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion
000148228 700__ $$aSaenz del Burgo, L
000148228 700__ $$aHernandez, R.M
000148228 700__ $$aOrive, G
000148228 700__ $$aSelden, C
000148228 700__ $$aFuller, B
000148228 700__ $$0(orcid)0000-0002-8666-622X$$aCiriza, J
000148228 700__ $$aPedraz, J.L
000148228 773__ $$g281 (2018), 119-138$$pJ. control. release$$tJOURNAL OF CONTROLLED RELEASE$$x0168-3659
000148228 8564_ $$s1121325$$uhttps://zaguan.unizar.es/record/148228/files/texto_completo.pdf$$yPostprint
000148228 8564_ $$s1112006$$uhttps://zaguan.unizar.es/record/148228/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148228 909CO $$ooai:zaguan.unizar.es:148228$$particulos$$pdriver
000148228 951__ $$a2025-01-15-15:14:37
000148228 980__ $$aARTICLE