000148254 001__ 148254 000148254 005__ 20250127144948.0 000148254 0247_ $$2doi$$a10.1016/j.chroma.2012.02.039 000148254 0248_ $$2sideral$$a76506 000148254 037__ $$aART-2012-76506 000148254 041__ $$aeng 000148254 100__ $$0(orcid)0000-0003-2638-9221$$aCanellas,E. 000148254 245__ $$aAtmospheric pressure gas chromatography coupled to quadrupole-time of flight mass spectrometry as a powerful tool for identification of non intentionally added substances in acrylic adhesives used in food packaging materials 000148254 260__ $$c2012 000148254 5060_ $$aAccess copy available to the general public$$fUnrestricted 000148254 5203_ $$aAcrylic adhesives are used to manufacture multilayer laminates that are used in food packaging to form the geometric shape of the package as well as to stick labels on the packages. Once applied on the packaging adhesives can supply potential migrants that could endanger the packaged food. Adhesives are complex matrices where intentionally and non intentionally added substances are present, but the identification of the migrants is required by law. In this study atmospheric pressure gas chromatography coupled to a quadrupole hyphenated to a time of flight mass spectrometer (APGC–MS/Q-TOF) has been explored for identification of unknowns coming from three different acrylic adhesives. The results are compared to those obtained by conventional GC–MS-Q (quadrupole). Sixteen compounds were identified by GC–MS/Q and five of them were confirmed by APGC–MS/Q-TOF as their molecular ions were found. Moreover, additional three new compounds were identified and their structure was elucidated working with the spectra obtained by APGC–MS/Q-TOF. This finding was very relevant as these compounds were biocides suspected to be allergenic and cytotoxic in humans. Migration studies were carried out using Tenax as solid food simulant and the results showed that the three acrylic adhesives tested in this work were safe for being used in food packaging materials since the migration of compounds previously identified was below the limit established in the current legislation. 000148254 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000148254 590__ $$a4.612$$b2012 000148254 591__ $$aCHEMISTRY, ANALYTICAL$$b6 / 74 = 0.081$$c2012$$dQ1$$eT1 000148254 591__ $$aBIOCHEMICAL RESEARCH METHODS$$b12 / 74 = 0.162$$c2012$$dQ1$$eT1 000148254 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000148254 700__ $$0(orcid)0000-0002-8765-4319$$aVera,P.$$uUniversidad de Zaragoza 000148254 700__ $$0(orcid)0000-0001-8893-0963$$aDomeño,C.$$uUniversidad de Zaragoza 000148254 700__ $$0(orcid)0000-0002-3703-7902$$aAlfaro,P.$$uUniversidad de Zaragoza 000148254 700__ $$0(orcid)0000-0003-2685-5739$$aNerín,C.$$uUniversidad de Zaragoza 000148254 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000148254 7102_ $$12009$$2X$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cProy. investigación HVA 000148254 773__ $$g1235 (2012), 141-148$$pJ. chromatogr. A$$tJournal of Chromatography A$$x0021-9673 000148254 8564_ $$s671277$$uhttps://zaguan.unizar.es/record/148254/files/texto_completo.pdf$$yPostprint 000148254 8564_ $$s2376212$$uhttps://zaguan.unizar.es/record/148254/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000148254 909CO $$ooai:zaguan.unizar.es:148254$$particulos$$pdriver 000148254 951__ $$a2025-01-27-14:45:22 000148254 980__ $$aARTICLE