148254 20250127144948.0 doi 10.1016/j.chroma.2012.02.039 sideral 76506 ART-2012-76506 eng Canellas,E. (orcid)0000-0003-2638-9221 Atmospheric pressure gas chromatography coupled to quadrupole-time of flight mass spectrometry as a powerful tool for identification of non intentionally added substances in acrylic adhesives used in food packaging materials 2012 Access copy available to the general public Unrestricted Acrylic adhesives are used to manufacture multilayer laminates that are used in food packaging to form the geometric shape of the package as well as to stick labels on the packages. Once applied on the packaging adhesives can supply potential migrants that could endanger the packaged food. Adhesives are complex matrices where intentionally and non intentionally added substances are present, but the identification of the migrants is required by law. In this study atmospheric pressure gas chromatography coupled to a quadrupole hyphenated to a time of flight mass spectrometer (APGC–MS/Q-TOF) has been explored for identification of unknowns coming from three different acrylic adhesives. The results are compared to those obtained by conventional GC–MS-Q (quadrupole). Sixteen compounds were identified by GC–MS/Q and five of them were confirmed by APGC–MS/Q-TOF as their molecular ions were found. Moreover, additional three new compounds were identified and their structure was elucidated working with the spectra obtained by APGC–MS/Q-TOF. This finding was very relevant as these compounds were biocides suspected to be allergenic and cytotoxic in humans. Migration studies were carried out using Tenax as solid food simulant and the results showed that the three acrylic adhesives tested in this work were safe for being used in food packaging materials since the migration of compounds previously identified was below the limit established in the current legislation. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.612 2012 CHEMISTRY, ANALYTICAL 6 / 74 = 0.081 2012 Q1 T1 BIOCHEMICAL RESEARCH METHODS 12 / 74 = 0.162 2012 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Vera,P. Universidad de Zaragoza (orcid)0000-0002-8765-4319 Domeño,C. Universidad de Zaragoza (orcid)0000-0001-8893-0963 Alfaro,P. Universidad de Zaragoza (orcid)0000-0002-3703-7902 Nerín,C. Universidad de Zaragoza (orcid)0000-0003-2685-5739 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 2009 X Universidad de Zaragoza Dpto. Química Analítica Proy. investigación HVA 1235 (2012), 141-148 J. chromatogr. A Journal of Chromatography A 0021-9673 671277 http://zaguan.unizar.es/record/148254/files/texto_completo.pdf Postprint 2376212 http://zaguan.unizar.es/record/148254/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:148254 articulos driver 2025-01-27-14:45:22 ARTICLE