000148270 001__ 148270
000148270 005__ 20250117145309.0
000148270 0247_ $$2doi$$a10.1016/j.atherosclerosis.2021.01.015
000148270 0248_ $$2sideral$$a123167
000148270 037__ $$aART-2021-123167
000148270 041__ $$aeng
000148270 100__ $$aMarco-Benedí, V.$$uUniversidad de Zaragoza
000148270 245__ $$aMaternally inherited hypercholesterolemia does not modify the cardiovascular phenotype in familial hypercholesterolemia
000148270 260__ $$c2021
000148270 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148270 5203_ $$aBackground and aims: Familial hypercholesterolemia (FH) is a codominant autosomal disease characterized by a high risk of cardiovascular disease when not in lipid-lowering treatment. However, there is a large variability in the clinical presentation in heterozygous subjects (HeFH). Maternal hypercholesterolemia has been proposed as a cardiometabolic risk factor later in life. Whether this phenotype variability depends on the mother or father origin of hypercholesterolemia is unknown. The objective of this study was to analyze potential differences in anthropometry, superficial lipid deposits, comorbidities, and lipid concentrations depending on the parental origin of hypercholesterolemia within a large group of HeFH. Methods: This is a cross-sectional observational, multicenter, nation-wide study in Spain. We recruited adults with HeFH to study clinical differences according to the parental origin. Data on HeFH patients were obtained from the Dyslipidemia Registry of the Spanish Atherosclerosis Society. Results: HeFH patients were grouped in 1231 HeFH-mother-offspring aged 45.7 (16.3) years and 1174 HeFH-father-offspring aged 44.8 (16.7) years. We did not find any difference in lipid parameters (total cholesterol, triglycerides, LDLc, HDLc, and Lp(a)), nor in the comorbidities studied (cardiovascular disease prevalence, age of onset of cardiovascular disease, obesity, diabetes, and hypertension) between groups. Lipid-lowering treatment did not differ between groups. The prevalence of comorbidities did not show differences when they were studied by age groups. Conclusions: Our research with a large group of subjects with HeFH shows that a potential maternal effect is not relevant in FH. However, due to the size of our sample, potential differences between genders cannot be completely ruled out. This implies that severe maternal hypercholesterolemia during pregnancy is not associated with additional risk in the FH affected offspring.
000148270 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B14$$9info:eu-repo/grantAgreement/ES/ISCIII-MINECO/PI19-00694$$9info:eu-repo/grantAgreement/ES/MICINN-ISCIII/PI18-01777
000148270 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000148270 590__ $$a6.851$$b2021
000148270 591__ $$aPERIPHERAL VASCULAR DISEASE$$b11 / 67 = 0.164$$c2021$$dQ1$$eT1
000148270 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b35 / 143 = 0.245$$c2021$$dQ1$$eT1
000148270 592__ $$a1.399$$b2021
000148270 593__ $$aCardiology and Cardiovascular Medicine$$c2021$$dQ1
000148270 594__ $$a8.7$$b2021
000148270 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148270 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M.$$uUniversidad de Zaragoza
000148270 700__ $$aBea, A.M.
000148270 700__ $$aSuarez-Tembra, M.
000148270 700__ $$aPlana, N.
000148270 700__ $$aPinto, X.
000148270 700__ $$aBrea, A.
000148270 700__ $$aSanchez-Hernandez, R.M.
000148270 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza
000148270 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148270 773__ $$g320 (2021), 47-52$$pAtherosclerosis$$tAtherosclerosis$$x0021-9150
000148270 8564_ $$s4286083$$uhttps://zaguan.unizar.es/record/148270/files/texto_completo.pdf$$yPostprint
000148270 8564_ $$s970110$$uhttps://zaguan.unizar.es/record/148270/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148270 909CO $$ooai:zaguan.unizar.es:148270$$particulos$$pdriver
000148270 951__ $$a2025-01-17-14:45:02
000148270 980__ $$aARTICLE