148330 20250116161253.0 doi 10.1039/c4sc01684j sideral 87943 ART-2014-87943 eng Fernández-Moreira, Vanesa Universidad de Zaragoza (orcid)0000-0002-1218-7218 Luminescent Re(i) and Re(i)/Au(i) complexes as cooperative partners in cell imaging and cancer therapy 2014 A series of luminescent monometallic fac-[Re(bipy)(CO)3(L)]+ and heterometallic fac-[Re(bipy)(CO)3(L-AuPPh3)]+ complexes, where L is an imidazole, alkynyl-imidazole or alkynyl-pyridine derivative, have been synthesised for the purpose of finding a synergic effect between the excellent photophysical properties of rhenium complexes and the good antiproliferative effects of gold compounds. Cytotoxicity studies performed in human A549 lung cancer cells revealed the importance of the alkynyl–phosphine–gold fragment within the probe to design efficient anticancer agents. Heterometallic Re(I)/Au(I) derivatives presented values of IC50 more than 10 times lower than their analogous Re(I) complexes. In addition, fluorescent cell microscopy pointed out the different biodistribution behaviour of the monometallic and heterometallic families. Whereas the monometallic Re(I) species showed some general cytoplasmatic staining with mitochondrial accumulation, the heterometallic Re(I)/Au(I) derivatives shifted from localising in the mitochondria to the nucleus and nucleolus upon increasing the loading concentration, suggesting a completely different driving force for their localisation pattern. These facts revealed that these bimetallic species can be excellent partners in cell imaging and cancer therapy. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA-FSE/B16 info:eu-repo/grantAgreement/ES/DGA-FSE/E77 info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2010-20500-C02-0 info:eu-repo/grantAgreement/ES/MINECO-FEDER/SAF2010-14920 info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 9.211 2014 CHEMISTRY, MULTIDISCIPLINARY 14 / 154 = 0.091 2014 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Marzo, Isabel Universidad de Zaragoza (orcid)0000-0002-2315-9079 Gimeno, M. Concepción Universidad de Zaragoza (orcid)0000-0003-0553-0695 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 2010 X Universidad de Zaragoza Dpto. Química Inorgánica Proy. investigación HWA 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 5, 11 (2014), 4434-4446 Chem. sci. CHEMICAL SCIENCE 2041-6520 1190479 http://zaguan.unizar.es/record/148330/files/texto_completo.pdf Postprint 2705127 http://zaguan.unizar.es/record/148330/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:148330 articulos driver 2025-01-16-14:31:25 ARTICLE