000148349 001__ 148349
000148349 005__ 20250116161254.0
000148349 0247_ $$2doi$$a10.1111/tbed.13366
000148349 0248_ $$2sideral$$a115277
000148349 037__ $$aART-2020-115277
000148349 041__ $$aeng
000148349 100__ $$aSevilla, Iker A.
000148349 245__ $$aTuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain
000148349 260__ $$c2020
000148349 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148349 5203_ $$aAnimal tuberculosis remains a great source of socioeconomic and health concern worldwide. Its main causative agents, Mycobacterium bovis and Mycobacterium caprae, have been isolated from many different domestic and wild animals. Naturally, occurring tuberculosis is extremely rare in rabbits, and implication of M. caprae has never been reported earlier. This study describes a severe tuberculosis outbreak caused by M. caprae in a Spanish farm of rabbits raised for meat for human consumption. The disease was first identified in a cachectic dam, and then it was confirmed in ten does with similar clinical signs. Subsequently, a depopulation operation was ordered for public health, animal welfare and environmental reasons. To broaden knowledge of spontaneous tuberculosis in rabbits, a study focused on pathological, epidemiological and diagnostic aspects was carried out on 51 does and 16 kittens after receiving the necessary authorizations. These animals were subjected to a modified intradermal test. After being euthanized, rabbits were examined for the presence of visible tuberculosis-compatible lesions. Lung, kidney, caecal appendix and sacculus rotundus samples underwent microbiological and anatomopathological analysis. Infection was revealed by at least one of the methods used in 71% of dams and in 44% of kittens. The intradermal test was shown to be a good indicator of infection. Lung was the tissue for which more animals were positive but renal and intestinal tissues were also affected in many cases. Apparently, M. caprae spread mainly through the aerogenous route. Infection was pathologically characterized by the absence of evident fibrous capsules surrounding granulomas. A spoligotype (SB0415) frequently found in this area was considered responsible for the outbreak but the source could not be established. Regardless of the exceptional nature of animal tuberculosis in this host, rabbit industry might not escape from its effects and therefore, current biosafety and surveillance strategies should also consider this disease.
000148349 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148349 590__ $$a5.005$$b2020
000148349 591__ $$aVETERINARY SCIENCES$$b4 / 146 = 0.027$$c2020$$dQ1$$eT1
000148349 591__ $$aINFECTIOUS DISEASES$$b23 / 92 = 0.25$$c2020$$dQ1$$eT1
000148349 592__ $$a1.391$$b2020
000148349 593__ $$aVeterinary (miscellaneous)$$c2020$$dQ1
000148349 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000148349 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148349 700__ $$0(orcid)0000-0002-6770-3400$$aArnal, María Cruz$$uUniversidad de Zaragoza
000148349 700__ $$aFuertes, Miguel
000148349 700__ $$aMartín, Elvira
000148349 700__ $$0(orcid)0000-0003-2085-2633$$aComenge, Jesús$$uUniversidad de Zaragoza
000148349 700__ $$aElguezabal, Natalia
000148349 700__ $$0(orcid)0000-0003-3289-4267$$aFernández de Luco, Daniel$$uUniversidad de Zaragoza
000148349 700__ $$aGarrido, Joseba M.
000148349 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000148349 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal
000148349 773__ $$g67, 1 (2020), 431-441$$pTransboundary and Emerging Diseases$$tTransboundary and Emerging Diseases$$x1865-1674
000148349 8564_ $$s1512754$$uhttps://zaguan.unizar.es/record/148349/files/texto_completo.pdf$$yPostprint
000148349 8564_ $$s1043668$$uhttps://zaguan.unizar.es/record/148349/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148349 909CO $$ooai:zaguan.unizar.es:148349$$particulos$$pdriver
000148349 951__ $$a2025-01-16-14:31:45
000148349 980__ $$aARTICLE