000148360 001__ 148360
000148360 005__ 20250116161254.0
000148360 0247_ $$2doi$$a10.1183/13993003.03042-2021
000148360 0248_ $$2sideral$$a128964
000148360 037__ $$aART-2022-128964
000148360 041__ $$aeng
000148360 100__ $$aCortese, R.
000148360 245__ $$aEpigenetic age acceleration in obstructive sleep apnoea is reversible with adherent treatment
000148360 260__ $$c2022
000148360 5203_ $$aObstructive sleep apnoea (OSA) leads to activation and propagation of oxidative stress and systemic inflammatory pathways, essentially mimicking accelerated biological ageing (senescence). Biological ageing is a complex and time-dependent deterioration of physiological processes with attendant morbidity and mortality. During ageing there is continuous and accelerated accumulation of epigenetic changes manifesting either systemically or restricted to a specific tissue/cell type. Epigenetic clocks, or DNA methylation clocks, have emerged as valuable biological age prediction tools. By regressing DNA methylation age on chronological age, epigenetic clocks can determine whether biological age acceleration occurs in certain diseases or in response to environmental factors. Using this approach, age acceleration measurements in blood were abnormally high in the context of common conditions such as obesity, neurological diseases and cigarette smoking.
000148360 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148360 590__ $$a24.9$$b2022
000148360 591__ $$aRESPIRATORY SYSTEM$$b2 / 66 = 0.03$$c2022$$dQ1$$eT1
000148360 592__ $$a4.722$$b2022
000148360 593__ $$aPulmonary and Respiratory Medicine$$c2022$$dQ1
000148360 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000148360 594__ $$a25.3$$b2022
000148360 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148360 700__ $$0(orcid)0000-0002-5228-248X$$aSanz-Rubio, D.
000148360 700__ $$aKheirandish-Gozal, L.
000148360 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J. M.$$uUniversidad de Zaragoza
000148360 700__ $$aGozal, D.
000148360 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148360 773__ $$g59, 4 (2022), 2103042$$pEur. respir. j.$$tEuropean respiratory journal$$x0903-1936
000148360 8564_ $$s458828$$uhttps://zaguan.unizar.es/record/148360/files/texto_completo.pdf$$yVersión publicada
000148360 8564_ $$s2743002$$uhttps://zaguan.unizar.es/record/148360/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148360 909CO $$ooai:zaguan.unizar.es:148360$$particulos$$pdriver
000148360 951__ $$a2025-01-16-14:31:58
000148360 980__ $$aARTICLE