000148365 001__ 148365
000148365 005__ 20251219150011.0
000148365 0247_ $$2doi$$a10.1016/j.euroneuro.2018.02.003
000148365 0248_ $$2sideral$$a136786
000148365 037__ $$aART-2018-136786
000148365 041__ $$aeng
000148365 100__ $$aPortero-Tresserra, Marta
000148365 245__ $$aMaternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex
000148365 260__ $$c2018
000148365 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148365 5203_ $$aChildhood adversity is associated with an increased risk of mood, anxiety and substance use disorders. Maternal separation is a reliable rodent model of early life adversity that leads to depression-like symptoms, which may increase the vulnerability to alcohol consumption during adolescence. However, the specific alterations in the pattern of alcohol consumption induced by maternal separation and the underlying molecular mechanisms are still unclear. The purpose of this study is to evaluate the long-term effects of maternal separation with early weaning (MSEW) on emotional and social behaviour, alcohol rewarding properties, and alcohol consumption, abstinence and relapse in adolescent male C57BL/6 mice. In addition, endocannabinoid and monoamine levels were analysed in discrete brain areas. Results showed that MSEW mice presented emotional alterations related to depressive-like behaviour and modified endocannabinoid levels in the striatum and the prefrontal cortex. MSEW mice also showed impairments in alcohol-induced conditioned place preference and higher alcohol intake in a model of binge drinking. Moreover, MSEW animals displayed a higher propensity to relapse in the two-bottle choice paradigm following a period of alcohol abstinence associated with reduced monoamine levels in the striatum. Such results indicate that exposure to early life stress increased the vulnerability to alcohol binge-drinking during adolescence, which may be partially explained by decreased sensitivity to alcohol rewarding properties and the ability to potentiate alcohol intake following a period of abstinence.
000148365 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CPII16-00027$$9info:eu-repo/grantAgreement/ES/MINECO SAF2016-75966-R$$9info:eu-repo/grantAgreement/ES/MSCBS/Plan Nacional sobre Drogas 02-2014
000148365 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000148365 590__ $$a4.468$$b2018
000148365 591__ $$aCLINICAL NEUROLOGY$$b33 / 199 = 0.166$$c2018$$dQ1$$eT1
000148365 591__ $$aPSYCHIATRY$$b27 / 146 = 0.185$$c2018$$dQ1$$eT1
000148365 591__ $$aPHARMACOLOGY & PHARMACY$$b35 / 266 = 0.132$$c2018$$dQ1$$eT1
000148365 591__ $$aNEUROSCIENCES$$b63 / 266 = 0.237$$c2018$$dQ1$$eT1
000148365 592__ $$a1.911$$b2018
000148365 593__ $$aBiological Psychiatry$$c2018$$dQ1
000148365 593__ $$aNeurology$$c2018$$dQ1
000148365 593__ $$aPsychiatry and Mental Health$$c2018$$dQ1
000148365 593__ $$aPharmacology$$c2018$$dQ1
000148365 593__ $$aPharmacology (medical)$$c2018$$dQ1
000148365 593__ $$aNeurology (clinical)$$c2018$$dQ1
000148365 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148365 700__ $$0(orcid)0000-0003-1028-8581$$aGracia-Rubio, Irene
000148365 700__ $$aCantacorps, Lídia
000148365 700__ $$aPozo, Oscar J.
000148365 700__ $$aGómez-Gómez, Alejandro
000148365 700__ $$aPastor, Antoni
000148365 700__ $$aLópez-Arnau, Raúl
000148365 700__ $$ade la Torre, Rafael
000148365 700__ $$aValverde, Olga
000148365 773__ $$g28, 4 (2018), [41 pp.]$$pEur. neuropsychopharmacol.$$tEUROPEAN NEUROPSYCHOPHARMACOLOGY$$x0924-977X
000148365 8564_ $$s508426$$uhttps://zaguan.unizar.es/record/148365/files/texto_completo.pdf$$yPostprint
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000148365 909CO $$ooai:zaguan.unizar.es:148365$$particulos$$pdriver
000148365 951__ $$a2025-12-19-14:58:17
000148365 980__ $$aARTICLE