148365 20251219150011.0 doi 10.1016/j.euroneuro.2018.02.003 sideral 136786 ART-2018-136786 eng Portero-Tresserra, Marta Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex 2018 Access copy available to the general public Unrestricted Childhood adversity is associated with an increased risk of mood, anxiety and substance use disorders. Maternal separation is a reliable rodent model of early life adversity that leads to depression-like symptoms, which may increase the vulnerability to alcohol consumption during adolescence. However, the specific alterations in the pattern of alcohol consumption induced by maternal separation and the underlying molecular mechanisms are still unclear. The purpose of this study is to evaluate the long-term effects of maternal separation with early weaning (MSEW) on emotional and social behaviour, alcohol rewarding properties, and alcohol consumption, abstinence and relapse in adolescent male C57BL/6 mice. In addition, endocannabinoid and monoamine levels were analysed in discrete brain areas. Results showed that MSEW mice presented emotional alterations related to depressive-like behaviour and modified endocannabinoid levels in the striatum and the prefrontal cortex. MSEW mice also showed impairments in alcohol-induced conditioned place preference and higher alcohol intake in a model of binge drinking. Moreover, MSEW animals displayed a higher propensity to relapse in the two-bottle choice paradigm following a period of alcohol abstinence associated with reduced monoamine levels in the striatum. Such results indicate that exposure to early life stress increased the vulnerability to alcohol binge-drinking during adolescence, which may be partially explained by decreased sensitivity to alcohol rewarding properties and the ability to potentiate alcohol intake following a period of abstinence. info:eu-repo/grantAgreement/ES/ISCIII/CPII16-00027 info:eu-repo/grantAgreement/ES/MINECO SAF2016-75966-R info:eu-repo/grantAgreement/ES/MSCBS/Plan Nacional sobre Drogas 02-2014 info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 4.468 2018 CLINICAL NEUROLOGY 33 / 199 = 0.166 2018 Q1 T1 PSYCHIATRY 27 / 146 = 0.185 2018 Q1 T1 PHARMACOLOGY & PHARMACY 35 / 266 = 0.132 2018 Q1 T1 NEUROSCIENCES 63 / 266 = 0.237 2018 Q1 T1 1.911 2018 Biological Psychiatry 2018 Q1 Neurology 2018 Q1 Psychiatry and Mental Health 2018 Q1 Pharmacology 2018 Q1 Pharmacology (medical) 2018 Q1 Neurology (clinical) 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Gracia-Rubio, Irene (orcid)0000-0003-1028-8581 Cantacorps, Lídia Pozo, Oscar J. Gómez-Gómez, Alejandro Pastor, Antoni López-Arnau, Raúl de la Torre, Rafael Valverde, Olga 28, 4 (2018), [41 pp.] Eur. neuropsychopharmacol. EUROPEAN NEUROPSYCHOPHARMACOLOGY 0924-977X 508426 http://zaguan.unizar.es/record/148365/files/texto_completo.pdf Postprint 962068 http://zaguan.unizar.es/record/148365/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:148365 articulos driver 2025-12-19-14:58:17 ARTICLE