000148368 001__ 148368
000148368 005__ 20250520101729.0
000148368 0247_ $$2doi$$a10.1177/0269881116681457
000148368 0248_ $$2sideral$$a136782
000148368 037__ $$aART-2016-136782
000148368 041__ $$aeng
000148368 100__ $$aEsteve-Arenys, Anna
000148368 245__ $$aBinge ethanol drinking during adolescence modifies cocaine responses in mice
000148368 260__ $$c2016
000148368 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148368 5203_ $$aBinge ethanol drinking is an emerging pattern of excessive consumption among adolescents and young adults. Repeated ethanol intoxication has negative consequences during critical periods of brain development. Therefore, binge ethanol intake represents a vulnerability factor that promotes subsequent manifestations of neuropsychiatric disorders. In this study, we investigated the effects of oral binge ethanol intake during adolescence on the subsequent effects of cocaine in C57BL/6 mice. Firstly, we evaluated the oral ethanol intake of two binge ethanol procedures with different ethanol concentrations (20% v/v versus 30%, v/v). The highest ethanol intake was found in mice exposed to the lower ethanol concentration (20% v/v). In a second experiment, mice exposed to binge ethanol procedure were evaluated to study the effects of cocaine on locomotor activity, behavioural sensitization, and the reinforcing effects of cocaine in the self-administration paradigm. Mice exposed to ethanol binging showed discrete detrimental effects in responses to cocaine in the different experiments evaluated. Our findings revealed that the pattern of binge ethanol consumption in adolescent mice here evaluated produced a weak facilitation of cocaine responses. The present study highlights the importance of interventions to limit the deleterious effects of binge ethanol drinking during adolescence.
000148368 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/PSI2014-51847-R$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2013-41761-R
000148368 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000148368 590__ $$a4.179$$b2016
000148368 591__ $$aCLINICAL NEUROLOGY$$b37 / 193 = 0.192$$c2016$$dQ1$$eT1
000148368 591__ $$aPSYCHOLOGY, EXPERIMENTAL$$b30 / 142 = 0.211$$c2016$$dQ1$$eT1
000148368 591__ $$aPHARMACOLOGY & PHARMACY$$b42 / 256 = 0.164$$c2016$$dQ1$$eT1
000148368 591__ $$aNEUROSCIENCES$$b64 / 257 = 0.249$$c2016$$dQ1$$eT1
000148368 592__ $$a2.095$$b2016
000148368 593__ $$aMedicine (miscellaneous)$$c2016$$dQ1
000148368 593__ $$aPsychiatry and Mental Health$$c2016$$dQ1
000148368 593__ $$aPharmacology (medical)$$c2016$$dQ1
000148368 593__ $$aPharmacology$$c2016$$dQ1
000148368 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148368 700__ $$0(orcid)0000-0003-1028-8581$$aGracia-Rubio, Irene
000148368 700__ $$aCantacorps, Lídia
000148368 700__ $$aPozo, Oscar J.
000148368 700__ $$aMarcos, Josep
000148368 700__ $$aRodríguez-Árias, Marta
000148368 700__ $$aMiñarro, José
000148368 700__ $$aValverde, Olga
000148368 773__ $$g31, 1 (2016), 86-95$$pJ. psychopharmacol.$$tJOURNAL OF PSYCHOPHARMACOLOGY$$x0269-8811
000148368 8564_ $$s1171186$$uhttps://zaguan.unizar.es/record/148368/files/texto_completo.pdf$$yVersión publicada
000148368 8564_ $$s2551833$$uhttps://zaguan.unizar.es/record/148368/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148368 909CO $$ooai:zaguan.unizar.es:148368$$particulos$$pdriver
000148368 951__ $$a2025-05-20-10:14:04
000148368 980__ $$aARTICLE