148368 20250520101729.0 doi 10.1177/0269881116681457 sideral 136782 ART-2016-136782 eng Esteve-Arenys, Anna Binge ethanol drinking during adolescence modifies cocaine responses in mice 2016 Access copy available to the general public Unrestricted Binge ethanol drinking is an emerging pattern of excessive consumption among adolescents and young adults. Repeated ethanol intoxication has negative consequences during critical periods of brain development. Therefore, binge ethanol intake represents a vulnerability factor that promotes subsequent manifestations of neuropsychiatric disorders. In this study, we investigated the effects of oral binge ethanol intake during adolescence on the subsequent effects of cocaine in C57BL/6 mice. Firstly, we evaluated the oral ethanol intake of two binge ethanol procedures with different ethanol concentrations (20% v/v versus 30%, v/v). The highest ethanol intake was found in mice exposed to the lower ethanol concentration (20% v/v). In a second experiment, mice exposed to binge ethanol procedure were evaluated to study the effects of cocaine on locomotor activity, behavioural sensitization, and the reinforcing effects of cocaine in the self-administration paradigm. Mice exposed to ethanol binging showed discrete detrimental effects in responses to cocaine in the different experiments evaluated. Our findings revealed that the pattern of binge ethanol consumption in adolescent mice here evaluated produced a weak facilitation of cocaine responses. The present study highlights the importance of interventions to limit the deleterious effects of binge ethanol drinking during adolescence. info:eu-repo/grantAgreement/ES/MINECO/PSI2014-51847-R info:eu-repo/grantAgreement/ES/MINECO/SAF2013-41761-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.179 2016 CLINICAL NEUROLOGY 37 / 193 = 0.192 2016 Q1 T1 PSYCHOLOGY, EXPERIMENTAL 30 / 142 = 0.211 2016 Q1 T1 PHARMACOLOGY & PHARMACY 42 / 256 = 0.164 2016 Q1 T1 NEUROSCIENCES 64 / 257 = 0.249 2016 Q1 T1 2.095 2016 Medicine (miscellaneous) 2016 Q1 Psychiatry and Mental Health 2016 Q1 Pharmacology (medical) 2016 Q1 Pharmacology 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gracia-Rubio, Irene (orcid)0000-0003-1028-8581 Cantacorps, Lídia Pozo, Oscar J. Marcos, Josep Rodríguez-Árias, Marta Miñarro, José Valverde, Olga 31, 1 (2016), 86-95 J. psychopharmacol. JOURNAL OF PSYCHOPHARMACOLOGY 0269-8811 1171186 http://zaguan.unizar.es/record/148368/files/texto_completo.pdf Versión publicada 2551833 http://zaguan.unizar.es/record/148368/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:148368 articulos driver 2025-05-20-10:14:04 ARTICLE