000148371 001__ 148371
000148371 005__ 20250116161254.0
000148371 0247_ $$2doi$$a10.1016/j.arbres.2021.05.019
000148371 0248_ $$2sideral$$a141359
000148371 037__ $$aART-2021-141359
000148371 041__ $$aeng
000148371 100__ $$aMasa, Juan F.
000148371 245__ $$aEffectiveness of CPAP vs. Noninvasive Ventilation Based on Disease Severity in Obesity Hypoventilation Syndrome and Concomitant Severe Obstructive Sleep Apnea
000148371 260__ $$c2021
000148371 5203_ $$aRationale: Obesity hypoventilation syndrome (OHS) with concomitant severe obstructive sleep apnea (OSA) is treated with CPAP or noninvasive ventilation (NIV) during sleep. NIV is costlier, but may be advantageous because it provides ventilatory support. However, there are no long-term trials comparing these treatment modalities based on OHS severity.
Objective: To determine if CPAP have similar effectiveness when compared to NIV according to OHS severity subgroups.
Methods: Post hoc analysis of the Pickwick randomized clinical trial in which 215 ambulatory patients with untreated OHS and concomitant severe OSA, defined as apnoea-hypopnea index (AHI)≥30events/h, were allocated to NIV or CPAP. In the present analysis, the Pickwick cohort was divided in severity subgroups based on the degree of baseline daytime hypercapnia (PaCO2 of 45-49.9 or ≥50mmHg). Repeated measures of PaCO2 and PaO2 during the subsequent 3 years were compared between CPAP and NIV in the two severity subgroups. Statistical analysis was performed using linear mixed-effects model.
Results: 204 patients, 97 in the NIV group and 107 in the CPAP group were analyzed. The longitudinal improvements of PaCO2 and PaO2 were similar between CPAP and NIV based on the PaCO2 severity subgroups.
Conclusion: In ambulatory patients with OHS and concomitant severe OSA who were treated with NIV or CPAP, long-term NIV therapy was similar to CPAP in improving awake hypercapnia, regardless of the severity of baseline hypercapnia. Therefore, in this patient population, the decision to prescribe CPAP or NIV cannot be solely based on the presenting level of PaCO2
000148371 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII PI0540402
000148371 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148371 590__ $$a6.333$$b2021
000148371 591__ $$aRESPIRATORY SYSTEM$$b14 / 66 = 0.212$$c2021$$dQ1$$eT1
000148371 592__ $$a0.262$$b2021
000148371 593__ $$aPulmonary and Respiratory Medicine$$c2021$$dQ3
000148371 594__ $$a2.0$$b2021
000148371 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148371 700__ $$aBenítez, Iván D.
000148371 700__ $$aSánchez-Quiroga, Maria Á.
000148371 700__ $$aGomez de Terreros, Francisco J.
000148371 700__ $$aCorral, Jaime
000148371 700__ $$aRomero, Auxiliadora
000148371 700__ $$aCaballero-Eraso, Candela
000148371 700__ $$aOrdax-Carbajo, Estrella
000148371 700__ $$aTroncoso, Maria F.
000148371 700__ $$aGonzález, Mónica
000148371 700__ $$aLópez-Martín, Soledad
000148371 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, José M.$$uUniversidad de Zaragoza
000148371 700__ $$aMartí, Sergi
000148371 700__ $$aDíaz-Cambriles, Trinidad
000148371 700__ $$aChiner, Eusebi
000148371 700__ $$aEgea, Carlos
000148371 700__ $$aBarca, Javier
000148371 700__ $$aVázquez-Polo, Francisco J.
000148371 700__ $$aNegrín, Miguel A.
000148371 700__ $$aMartel-Escobar, María
000148371 700__ $$aBarbé, Ferrán
000148371 700__ $$aMokhlesi, Babak
000148371 700__ $$aRiesco, Juan A.
000148371 700__ $$aGallego, Rocio
000148371 700__ $$aGonzález-Mangado, Nicolás
000148371 700__ $$aGomez-Garcia, Teresa
000148371 700__ $$aMartinez-Martinez, Maria A.
000148371 700__ $$aOjeda-Castillejo, Elena
000148371 700__ $$aLópez-Padilla, Daniel
000148371 700__ $$aCarrizo, Santiago J.
000148371 700__ $$aGallego, Begoña
000148371 700__ $$aPallero, Mercedes
000148371 700__ $$aRomero, Odile
000148371 700__ $$aRamón, Maria A.
000148371 700__ $$aArias, Eva
000148371 700__ $$aMuñoz-Méndez, Jesús
000148371 700__ $$aSenent, Cristina
000148371 700__ $$aSancho-Chust, Jose N.
000148371 700__ $$aNavarro-Soriano, Nieves B.
000148371 700__ $$aBarrot, Emilia
000148371 700__ $$aBenítez, José M.
000148371 700__ $$aSanchez-Gómez, Jesús
000148371 700__ $$aGolpe, Rafael
000148371 700__ $$aGómez-Mendieta, María A.
000148371 700__ $$aGomez, Silvia
000148371 700__ $$aBengoa, Mónica
000148371 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148371 773__ $$g58, 3 (2021), 228-236$$pArch. bronconeumol.$$tArchivos de Bronconeumologia$$x0300-2896
000148371 8564_ $$s1164302$$uhttps://zaguan.unizar.es/record/148371/files/texto_completo.pdf$$yVersión publicada
000148371 8564_ $$s1642604$$uhttps://zaguan.unizar.es/record/148371/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148371 909CO $$ooai:zaguan.unizar.es:148371$$particulos$$pdriver
000148371 951__ $$a2025-01-16-14:32:10
000148371 980__ $$aARTICLE