148371 20250116161254.0 doi 10.1016/j.arbres.2021.05.019 sideral 141359 ART-2021-141359 eng Masa, Juan F. Effectiveness of CPAP vs. Noninvasive Ventilation Based on Disease Severity in Obesity Hypoventilation Syndrome and Concomitant Severe Obstructive Sleep Apnea 2021 Rationale: Obesity hypoventilation syndrome (OHS) with concomitant severe obstructive sleep apnea (OSA) is treated with CPAP or noninvasive ventilation (NIV) during sleep. NIV is costlier, but may be advantageous because it provides ventilatory support. However, there are no long-term trials comparing these treatment modalities based on OHS severity. Objective: To determine if CPAP have similar effectiveness when compared to NIV according to OHS severity subgroups. Methods: Post hoc analysis of the Pickwick randomized clinical trial in which 215 ambulatory patients with untreated OHS and concomitant severe OSA, defined as apnoea-hypopnea index (AHI)≥30events/h, were allocated to NIV or CPAP. In the present analysis, the Pickwick cohort was divided in severity subgroups based on the degree of baseline daytime hypercapnia (PaCO2 of 45-49.9 or ≥50mmHg). Repeated measures of PaCO2 and PaO2 during the subsequent 3 years were compared between CPAP and NIV in the two severity subgroups. Statistical analysis was performed using linear mixed-effects model. Results: 204 patients, 97 in the NIV group and 107 in the CPAP group were analyzed. The longitudinal improvements of PaCO2 and PaO2 were similar between CPAP and NIV based on the PaCO2 severity subgroups. Conclusion: In ambulatory patients with OHS and concomitant severe OSA who were treated with NIV or CPAP, long-term NIV therapy was similar to CPAP in improving awake hypercapnia, regardless of the severity of baseline hypercapnia. Therefore, in this patient population, the decision to prescribe CPAP or NIV cannot be solely based on the presenting level of PaCO2 info:eu-repo/grantAgreement/ES/ISCIII PI0540402 info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 6.333 2021 RESPIRATORY SYSTEM 14 / 66 = 0.212 2021 Q1 T1 0.262 2021 Pulmonary and Respiratory Medicine 2021 Q3 2.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Benítez, Iván D. Sánchez-Quiroga, Maria Á. Gomez de Terreros, Francisco J. Corral, Jaime Romero, Auxiliadora Caballero-Eraso, Candela Ordax-Carbajo, Estrella Troncoso, Maria F. González, Mónica López-Martín, Soledad Marin, José M. Universidad de Zaragoza (orcid)0000-0001-9096-2294 Martí, Sergi Díaz-Cambriles, Trinidad Chiner, Eusebi Egea, Carlos Barca, Javier Vázquez-Polo, Francisco J. Negrín, Miguel A. Martel-Escobar, María Barbé, Ferrán Mokhlesi, Babak Riesco, Juan A. Gallego, Rocio González-Mangado, Nicolás Gomez-Garcia, Teresa Martinez-Martinez, Maria A. Ojeda-Castillejo, Elena López-Padilla, Daniel Carrizo, Santiago J. Gallego, Begoña Pallero, Mercedes Romero, Odile Ramón, Maria A. Arias, Eva Muñoz-Méndez, Jesús Senent, Cristina Sancho-Chust, Jose N. Navarro-Soriano, Nieves B. Barrot, Emilia Benítez, José M. Sanchez-Gómez, Jesús Golpe, Rafael Gómez-Mendieta, María A. Gomez, Silvia Bengoa, Mónica 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 58, 3 (2021), 228-236 Arch. bronconeumol. Archivos de Bronconeumologia 0300-2896 1164302 http://zaguan.unizar.es/record/148371/files/texto_completo.pdf Versión publicada 1642604 http://zaguan.unizar.es/record/148371/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:148371 articulos driver 2025-01-16-14:32:10 ARTICLE