000148379 001__ 148379
000148379 005__ 20250120150148.0
000148379 0247_ $$2doi$$a10.1016/j.arbr.2021.04.012
000148379 0248_ $$2sideral$$a141360
000148379 037__ $$aART-2021-141360
000148379 041__ $$aeng
000148379 100__ $$aEzponda, Ana
000148379 245__ $$aPsoas Muscle Density Evaluated by Chest CT and Long-Term Mortality in COPD Patients
000148379 260__ $$c2021
000148379 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148379 5203_ $$aRationale: Poor muscle quality in COPD patients relates to exercise intolerance and mortality. Muscle quality can be estimated on computed tomography (CT) by estimating psoas density (PsD). We tested the hypothesis that PsD is lower in COPD patients than in controls and relates to all-cause mortality. Methods: At baseline, PsD was measured using axial low-dose chest CT images in 220 COPD patients,80% men, who were 65 ± 8 years old with mild to severe airflow limitation and in a control group of 58subjects matched by age, sex, body mass index (BMI) and body surface area (BSA). COPD patients were prospectively followed for 76.5 (48–119) months. Anthropometrics, smoking history, BMI, dyspnoea, lung function, exercise capacity, BODE index and exacerbations history were recorded. Cox proportional risk analysis determined the factors more strongly associated with long-term mortality. Results: PsD was lower in COPD patients than in controls (40.5 vs 42.5, p = 0.045). During the follow-up,54 (24.5%) deaths occurred in the COPD group. PsD as well as age, sex, pack-year history, FEV 1 %, 6MWD, mMRC, BODE index, were independently associated with mortality. Multivariate analysis showed that age (HR 1.06; 95% CI 1.02–1.12, p = 0.006) and CT-assessed PsD (HR 0.97; 95%CI 0.94–0.99, p = 0.023) were the variables independently associated with all-cause mortality. Conclusions: In COPD patients with mild to severe airflow limitation, chest CT-assessed psoas muscle density was lower than in matched controls and independently associated with long-term mortality. Muscle quality using the easy to evaluate psoas muscle density from chest CT may provide clinicians with important prognostic information in COPD.
000148379 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000148379 590__ $$a6.333$$b2021
000148379 591__ $$aRESPIRATORY SYSTEM$$b14 / 66 = 0.212$$c2021$$dQ1$$eT1
000148379 592__ $$a0.262$$b2021
000148379 593__ $$aPulmonary and Respiratory Medicine$$c2021$$dQ3
000148379 594__ $$a2.0$$b2021
000148379 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148379 700__ $$aCasanova, Ciro
000148379 700__ $$aCabrera, Carlos
000148379 700__ $$aMartin-Palmero, Ángela
000148379 700__ $$aMarin-Oto, Marta
000148379 700__ $$0(orcid)0000-0001-9096-2294$$aMarín, Jose M.$$uUniversidad de Zaragoza
000148379 700__ $$aPinto-Plata, Víctor
000148379 700__ $$aDivo, Miguel
000148379 700__ $$aCelli, Bartolome R.
000148379 700__ $$aZulueta, Javier J.
000148379 700__ $$aBastarrika, Gorka
000148379 700__ $$ade-Torres, Juan P.
000148379 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148379 773__ $$g57, 8 (2021), 533-539$$pArch. bronconeumol.$$tArchivos de Bronconeumologia$$x0300-2896
000148379 8564_ $$s753389$$uhttps://zaguan.unizar.es/record/148379/files/texto_completo.pdf$$yPostprint
000148379 8564_ $$s1320941$$uhttps://zaguan.unizar.es/record/148379/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148379 909CO $$ooai:zaguan.unizar.es:148379$$particulos$$pdriver
000148379 951__ $$a2025-01-20-14:59:51
000148379 980__ $$aARTICLE