000148380 001__ 148380
000148380 005__ 20250116161254.0
000148380 0247_ $$2doi$$a10.3390/jcm13237039
000148380 0248_ $$2sideral$$a141707
000148380 037__ $$aART-2024-141707
000148380 041__ $$aeng
000148380 100__ $$0(orcid)0009-0002-8859-5485$$aSevil-Pérez, Anais
000148380 245__ $$aThe Association Between Major Depression and Alzheimer’s Disease Risk: Evidence from a 12-Year Longitudinal Study
000148380 260__ $$c2024
000148380 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148380 5203_ $$aBackground: The relationship between depression, particularly major depression (MD), as a risk factor for Alzheimer’s disease (AD) is well established; however, its precise role remains contested. Findings from the fourth wave of the ZARADEMP longitudinal study provide further insights into the association between MD and AD risk. Objectives: This study aimed to examine the association between MD and incident AD, controlling for established risk factors. Methods: The study analyzed 4803 participants, of whom 4057 were followed over a 12-year period as part of the ZARADEMP longitudinal study. Depression was assessed using the GMS-AGECAT, and dementia was diagnosed according to DSM-IV criteria. The association between MD and incident AD was evaluated using Cox proportional hazards regression models. Results: The incidence of AD was approximately twice as high in participants with MD compared to those without (relative risk = 2.07; 95% CI: 0.85–5.03; p = 0.123). This risk was nearly threefold higher in the fully adjusted model. Conclusions: These findings underscore a significant association between MD and an increased risk of AD, emphasizing the need for vigilant monitoring and potential early intervention among individuals diagnosed with MD.
000148380 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B15-17R$$9info:eu-repo/grantAgreement/ES/DGA/B15-23R$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000148380 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000148380 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148380 700__ $$0(orcid)0000-0002-3360-7015$$aLópez-Antón, Raúl$$uUniversidad de Zaragoza
000148380 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, Patricia$$uUniversidad de Zaragoza
000148380 700__ $$0(orcid)0000-0003-2284-7862$$ade la Cámara, Concepción$$uUniversidad de Zaragoza
000148380 700__ $$0(orcid)0000-0003-0335-0404$$aGascón-Catalán, Ana$$uUniversidad de Zaragoza
000148380 700__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, Javier$$uUniversidad de Zaragoza
000148380 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000148380 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000148380 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000148380 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000148380 773__ $$g13, 23 (2024), 7039 [10 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000148380 8564_ $$s1747814$$uhttps://zaguan.unizar.es/record/148380/files/texto_completo.pdf$$yVersión publicada
000148380 8564_ $$s2678804$$uhttps://zaguan.unizar.es/record/148380/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148380 909CO $$ooai:zaguan.unizar.es:148380$$particulos$$pdriver
000148380 951__ $$a2025-01-16-14:32:21
000148380 980__ $$aARTICLE