doi:10.3390/jcm13237039engSevil-Pérez, AnaisLópez-Antón, RaúlGracia-García, Patriciade la Cámara, ConcepciónGascón-Catalán, AnaSantabárbara, JavierThe Association Between Major Depression and Alzheimer’s Disease Risk: Evidence from a 12-Year Longitudinal StudyART-2024-141707Background: The relationship between depression, particularly major depression (MD), as a risk factor for Alzheimer’s disease (AD) is well established; however, its precise role remains contested. Findings from the fourth wave of the ZARADEMP longitudinal study provide further insights into the association between MD and AD risk. Objectives: This study aimed to examine the association between MD and incident AD, controlling for established risk factors. Methods: The study analyzed 4803 participants, of whom 4057 were followed over a 12-year period as part of the ZARADEMP longitudinal study. Depression was assessed using the GMS-AGECAT, and dementia was diagnosed according to DSM-IV criteria. The association between MD and incident AD was evaluated using Cox proportional hazards regression models. Results: The incidence of AD was approximately twice as high in participants with MD compared to those without (relative risk = 2.07; 95% CI: 0.85–5.03; p = 0.123). This risk was nearly threefold higher in the fully adjusted model. Conclusions: These findings underscore a significant association between MD and an increased risk of AD, emphasizing the need for vigilant monitoring and potential early intervention among individuals diagnosed with MD.2024http://zaguan.unizar.es/record/14838010.3390/jcm13237039http://zaguan.unizar.es/record/148380oai:zaguan.unizar.es:148380info:eu-repo/grantAgreement/ES/DGA/B15-17Rinfo:eu-repo/grantAgreement/ES/DGA/B15-23Rinfo:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/19-01874info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321Einfo:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103Journal of Clinical Medicine 13, 23 (2024), 7039 [10 pp.]byhttps://creativecommons.org/licenses/by/4.0/deed.esinfo:eu-repo/semantics/openAccess