000148385 001__ 148385
000148385 005__ 20250116161254.0
000148385 0247_ $$2doi$$a10.1016/j.chest.2021.03.069
000148385 0248_ $$2sideral$$a141364
000148385 037__ $$aART-2021-141364
000148385 041__ $$aeng
000148385 100__ $$aCasanova, Ciro
000148385 245__ $$aNatural Course of the Diffusing Capacity of the Lungs for Carbon Monoxide in COPD
000148385 260__ $$c2021
000148385 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148385 5203_ $$aBackground
The value of the single-breath diffusing capacity of the lungs for carbon monoxide (Dlco) relates to outcomes for patients with COPD. However, little is known about the natural course of Dlco over time, intersubject variability, and factors that may influence Dlco progression.
Research Question
What is the natural course of Dlco in patients with COPD over time, and which other factors, including sex differences, could influence this progression?
Study Design and Methods
We phenotyped 602 smokers (women, 33%), of whom 506 (84%) had COPD and 96 (16%) had no airflow limitation. Lung function, including Dlco, was monitored annually over 5 years. A random coefficients model was used to evaluate Dlco changes over time.
Results
The mean (± SE) yearly decline in Dlco % in patients with COPD was 1.34% ± 0.015%/y. This was steeper compared with non-COPD control subjects (0.04% ± 0.032%/y; P = .004). Sixteen percent of the patients with COPD, vs 4.3% of the control subjects, had a statistically significant Dlco % slope annual decline (4.14%/y). At baseline, women with COPD had lower Dlco values (11.37% ± 2.27%; P < .001) in spite of a higher FEV1 % than men. Compared with men, women with COPD had a steeper Dlco annual decline of 0.89% ± 0.42%/y (P = .039).
Interpretation
Patients with COPD have an accelerated decline in Dlco compared with smokers without the disease. However, the decline is slow, and a testing interval of 3 to 4 years may be clinically informative. The lower and more rapid decline in Dlco values in women, compared with men, suggests a differential impact of sex in gas exchange function.
000148385 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000148385 590__ $$a11.393$$b2021
000148385 591__ $$aCRITICAL CARE MEDICINE$$b5 / 35 = 0.143$$c2021$$dQ1$$eT1
000148385 591__ $$aRESPIRATORY SYSTEM$$b6 / 66 = 0.091$$c2021$$dQ1$$eT1
000148385 592__ $$a2.264$$b2021
000148385 593__ $$aCritical Care and Intensive Care Medicine$$c2021$$dQ1
000148385 593__ $$aCardiology and Cardiovascular Medicine$$c2021$$dQ1
000148385 594__ $$a10.0$$b2021
000148385 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148385 700__ $$aGonzalez-Dávila, Enrique
000148385 700__ $$aMartínez-Gonzalez, Cristina
000148385 700__ $$aCosio, Borja G.
000148385 700__ $$aFuster, Antonia
000148385 700__ $$aFeu, Nuria
000148385 700__ $$aSolanes, Ingrid
000148385 700__ $$aCabrera, Carlos
000148385 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, José M.$$uUniversidad de Zaragoza
000148385 700__ $$aBalcells, Eva
000148385 700__ $$aPeces-Barba, Germán
000148385 700__ $$ade Torres, Juan P.
000148385 700__ $$aMarín-Oto, Marta
000148385 700__ $$aCalle, Myriam
000148385 700__ $$aGolpe, Rafael
000148385 700__ $$aOjeda, Elena
000148385 700__ $$aDivo, Miguel
000148385 700__ $$aPinto-Plata, Victor
000148385 700__ $$aAmado, Carlos
000148385 700__ $$aLópez-Campos, José Luis
000148385 700__ $$aCelli, Bartolome R.
000148385 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148385 773__ $$g160, 2 (2021), 481-490$$pChest$$tChest$$x0012-3692
000148385 8564_ $$s464901$$uhttps://zaguan.unizar.es/record/148385/files/texto_completo.pdf$$yPostprint
000148385 8564_ $$s2062560$$uhttps://zaguan.unizar.es/record/148385/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148385 909CO $$ooai:zaguan.unizar.es:148385$$particulos$$pdriver
000148385 951__ $$a2025-01-16-14:32:26
000148385 980__ $$aARTICLE