148385 20260112133315.0 doi 10.1016/j.chest.2021.03.069 sideral 141364 ART-2021-141364 eng Casanova, Ciro Natural Course of the Diffusing Capacity of the Lungs for Carbon Monoxide in COPD 2021 Access copy available to the general public Unrestricted Background The value of the single-breath diffusing capacity of the lungs for carbon monoxide (Dlco) relates to outcomes for patients with COPD. However, little is known about the natural course of Dlco over time, intersubject variability, and factors that may influence Dlco progression. Research Question What is the natural course of Dlco in patients with COPD over time, and which other factors, including sex differences, could influence this progression? Study Design and Methods We phenotyped 602 smokers (women, 33%), of whom 506 (84%) had COPD and 96 (16%) had no airflow limitation. Lung function, including Dlco, was monitored annually over 5 years. A random coefficients model was used to evaluate Dlco changes over time. Results The mean (± SE) yearly decline in Dlco % in patients with COPD was 1.34% ± 0.015%/y. This was steeper compared with non-COPD control subjects (0.04% ± 0.032%/y; P = .004). Sixteen percent of the patients with COPD, vs 4.3% of the control subjects, had a statistically significant Dlco % slope annual decline (4.14%/y). At baseline, women with COPD had lower Dlco values (11.37% ± 2.27%; P < .001) in spite of a higher FEV1 % than men. Compared with men, women with COPD had a steeper Dlco annual decline of 0.89% ± 0.42%/y (P = .039). Interpretation Patients with COPD have an accelerated decline in Dlco compared with smokers without the disease. However, the decline is slow, and a testing interval of 3 to 4 years may be clinically informative. The lower and more rapid decline in Dlco values in women, compared with men, suggests a differential impact of sex in gas exchange function. info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 11.393 2021 CRITICAL CARE MEDICINE 5 / 35 = 0.143 2021 Q1 T1 RESPIRATORY SYSTEM 6 / 66 = 0.091 2021 Q1 T1 2.264 2021 Critical Care and Intensive Care Medicine 2021 Q1 Cardiology and Cardiovascular Medicine 2021 Q1 10.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Gonzalez-Dávila, Enrique Martínez-Gonzalez, Cristina Cosio, Borja G. Fuster, Antonia Feu, Nuria Solanes, Ingrid Cabrera, Carlos Marin, José M. Universidad de Zaragoza (orcid)0000-0001-9096-2294 Balcells, Eva Peces-Barba, Germán de Torres, Juan P. Marín-Oto, Marta (orcid)0000-0003-0777-3850 Calle, Myriam Golpe, Rafael Ojeda, Elena Divo, Miguel Pinto-Plata, Victor Amado, Carlos López-Campos, José Luis Celli, Bartolome R. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 160, 2 (2021), 481-490 Chest Chest 0012-3692 464901 http://zaguan.unizar.es/record/148385/files/texto_completo.pdf Postprint 2062560 http://zaguan.unizar.es/record/148385/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:148385 articulos driver 2026-01-12-13:04:04 ARTICLE