000148437 001__ 148437
000148437 005__ 20250117162507.0
000148437 0247_ $$2doi$$a10.1021/acs.inorgchem.7b02470
000148437 0248_ $$2sideral$$a104261
000148437 037__ $$aART-2017-104261
000148437 041__ $$aeng
000148437 100__ $$aLuengo, Andrés
000148437 245__ $$aTrackable Metallodrugs Combining Luminescent Re(I) and Bioactive Au(I) Fragments
000148437 260__ $$c2017
000148437 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148437 5203_ $$aHetero-bimetallic and -trimetallic complexes were synthesized by the combination of different metallic fragments, a luminescent Re(I) species, and a bioactive Au(I) derivative. A ditopic P, N-donor ligand (L) was used as linker between both metals, affording six new bipyridine (bipy) Re(I)/Au(I) hetero-metallic complexes of the type fac-[Re(bipy)(CO)3(LAuCl)]+ (4-6) and [(fac-[Re(bipy)(CO)3(L)])2Au]3+ (7-9) after a thorough synthetic procedure. Their emission is associated with a triplet metal-to-ligand charge transfer (Re(dp) ¿ bipy(p*)) transition and red-shifted in polar solvents with lifetimes in the range of nanoseconds and quantum yield values up to 12.5%. Cytotoxicity values in A549 cells of hetero-trimetallic species are almost twice that for the hetero-bimetallic (ca. 37 vs 69 µM, respectively), being the L-Au fragment the source of the antiproliferative activity. Species 7 and 8 showed similar behavior by fluorescence microscopy, with a nonuniform cytoplasmatic distribution, a clear accumulation in single spots at the edge of the inner cell membrane as well as in areas within the nucleus. Preliminary studies suggest the DNA as one of the targets and passive diffusion as the entrance pathway.
000148437 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E77$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2015-70371-REDT$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P
000148437 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148437 590__ $$a4.7$$b2017
000148437 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b5 / 44 = 0.114$$c2017$$dQ1$$eT1
000148437 592__ $$a1.892$$b2017
000148437 593__ $$aChemistry (miscellaneous)$$c2017$$dQ1
000148437 593__ $$aPhysical and Theoretical Chemistry$$c2017$$dQ1
000148437 593__ $$aInorganic Chemistry$$c2017$$dQ1
000148437 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148437 700__ $$0(orcid)0000-0002-1218-7218$$aFernández-Moreira, Vanesa
000148437 700__ $$0(orcid)0000-0002-2315-9079$$aMarzo, Isabel$$uUniversidad de Zaragoza
000148437 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M. Concepción$$uUniversidad de Zaragoza
000148437 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000148437 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000148437 773__ $$g56, 24 (2017), 15159-15170$$pInorg. chem.$$tInorganic Chemistry$$x0020-1669
000148437 8564_ $$s1184300$$uhttps://zaguan.unizar.es/record/148437/files/texto_completo.pdf$$yPostprint
000148437 8564_ $$s1215920$$uhttps://zaguan.unizar.es/record/148437/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148437 909CO $$ooai:zaguan.unizar.es:148437$$particulos$$pdriver
000148437 951__ $$a2025-01-17-14:35:44
000148437 980__ $$aARTICLE