148437 20250117162507.0 doi 10.1021/acs.inorgchem.7b02470 sideral 104261 ART-2017-104261 eng Luengo, Andrés Trackable Metallodrugs Combining Luminescent Re(I) and Bioactive Au(I) Fragments 2017 Hetero-bimetallic and -trimetallic complexes were synthesized by the combination of different metallic fragments, a luminescent Re(I) species, and a bioactive Au(I) derivative. A ditopic P, N-donor ligand (L) was used as linker between both metals, affording six new bipyridine (bipy) Re(I)/Au(I) hetero-metallic complexes of the type fac-[Re(bipy)(CO)3(LAuCl)]+ (4-6) and [(fac-[Re(bipy)(CO)3(L)])2Au]3+ (7-9) after a thorough synthetic procedure. Their emission is associated with a triplet metal-to-ligand charge transfer (Re(dp) ¿ bipy(p*)) transition and red-shifted in polar solvents with lifetimes in the range of nanoseconds and quantum yield values up to 12.5%. Cytotoxicity values in A549 cells of hetero-trimetallic species are almost twice that for the hetero-bimetallic (ca. 37 vs 69 µM, respectively), being the L-Au fragment the source of the antiproliferative activity. Species 7 and 8 showed similar behavior by fluorescence microscopy, with a nonuniform cytoplasmatic distribution, a clear accumulation in single spots at the edge of the inner cell membrane as well as in areas within the nucleus. Preliminary studies suggest the DNA as one of the targets and passive diffusion as the entrance pathway. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA-FSE/E77 info:eu-repo/grantAgreement/ES/MINECO/CTQ2015-70371-REDT info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.7 2017 CHEMISTRY, INORGANIC & NUCLEAR 5 / 44 = 0.114 2017 Q1 T1 1.892 2017 Chemistry (miscellaneous) 2017 Q1 Physical and Theoretical Chemistry 2017 Q1 Inorganic Chemistry 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Fernández-Moreira, Vanesa (orcid)0000-0002-1218-7218 Marzo, Isabel Universidad de Zaragoza (orcid)0000-0002-2315-9079 Gimeno, M. Concepción Universidad de Zaragoza (orcid)0000-0003-0553-0695 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 1002 050 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Biología Celular 56, 24 (2017), 15159-15170 Inorg. chem. Inorganic Chemistry 0020-1669 1184300 http://zaguan.unizar.es/record/148437/files/texto_completo.pdf Postprint 1215920 http://zaguan.unizar.es/record/148437/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:148437 articulos driver 2025-01-17-14:35:44 ARTICLE