148467 20250117162507.0 doi 10.1016/j.rce.2015.06.003 sideral 93248 ART-2015-93248 spa Sáenz-Abad, D. Universidad de Zaragoza (orcid)0000-0003-1359-6424 Importancia pronóstica de la variabilidad glucémica sobre la mortalidad intrahospitalaria en pacientes ingresados en Medicina Interna 2015 Introduction The objective was to assess the prognostic importance of various glycaemic control measures on hospital mortality. Material and methods Retrospective, analytical cohort study that included patients hospitalised in internal medicine departments with a diagnosis related to diabetes mellitus (DM), excluding acute decompensations. The clinical endpoint was hospital mortality. We recorded clinical, analytical and glycaemic control-related variables (scheduled insulin administration, plasma glycaemia at admission, HbA1c, mean glycaemia (MG) and in-hospital glycaemic variability and hypoglycaemia). The measurement of hospital mortality predictors was performed using univariate and multivariate logistic regression. Results A total of 384 patients (50.3% men) were included. The mean age was 78.5 (SD, 10.3) years. The DM-related diagnoses were type 2 diabetes (83.6%) and stress hyperglycaemia (6.8%). Thirty-one (8.1%) patients died while in hospital. In the multivariate analysis, the best model for predicting mortality (R2 = 0.326; P<.0001) consisted, in order of importance, of age (¿2 = 8.19; OR = 1.094; 95% CI 1.020-1.174; P=.004), Charlson index (¿2 = 7.28; OR = 1.48; 95% CI 1.11-1.99; P=.007), initial glycaemia (¿2 = 6.05; OR = 1.007; 95% CI 1.001-1.014; P=.014), HbA1c (¿2 = 5.76; OR = 0.59; 95% CI 0.33-1; P=.016), glycaemic variability (¿2 = 4.41; OR = 1.031; 95% CI 1-1.062; P=.036), need for corticosteroid treatment (¿2 = 4.03; OR = 3.1; 95% CI 1-9.64; P=.045), administration of scheduled insulin (¿2 = 3.98; OR = 0.26; 95% CI 0.066-1; P=.046) and systolic blood pressure (¿2 = 2.92; OR = 0.985; 95% CI 0.97-1.003; P=.088). Conclusion An increase in initial glycaemia and in-hospital glycaemic variability predict the risk of mortality for hospitalised patients with DM. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 0.76 2015 MEDICINE, GENERAL & INTERNAL 105 / 153 = 0.686 2015 Q3 T3 0.186 2015 Medicine (miscellaneous) 2015 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gimeno-Orna, J. Pérez-Calvo, J. I. Universidad de Zaragoza (orcid)0000-0003-2361-9941 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 215, 9 (2015), 479-485 Rev. clín. esp. Revista Clínica Española 0014-2565 564376 http://zaguan.unizar.es/record/148467/files/texto_completo.pdf Versión publicada 1989699 http://zaguan.unizar.es/record/148467/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:148467 articulos driver 2025-01-17-14:36:23 ARTICLE