000148502 001__ 148502
000148502 005__ 20250117162508.0
000148502 0247_ $$2doi$$a10.1021/om300610j
000148502 0248_ $$2sideral$$a78958
000148502 037__ $$aART-2012-78958
000148502 041__ $$aeng
000148502 100__ $$0(orcid)0000-0002-1218-7218$$aFernández-Moreira, Vanesa
000148502 245__ $$aBioconjugated rhenium(I) complexes with amino acid derivatives: Synthesis, photophysical properties, and cell imaging studies
000148502 260__ $$c2012
000148502 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148502 5203_ $$aThe synthesis of a series of bioconjugated fac tricarbonyl rhenium bis-imine complexes with amino acid ester derivatives and their application in fluorescent microscopy cell imaging is reported. A range of meta- and para-bioconjugated pyridyl derivatives were synthesized, and their photophysical properties were analyzed upon coordination to fac-[Re(bipy)(CO)3(CF3SO3)]. Their long lifetimes (270–370 ns) and large Stokes shifts (>140 nm) suggested the new bioconjugated rhenium complexes could be strong candidates for cell imaging applications. All species were taken up by MCF-7 cells and seemed to have a distinct localization pattern. However, while cells incubated with para derivatives had an anomalous cellular growth pattern and suffered from photobleaching upon irradiation, promoting cellular death, those incubated with the meta derivatives behaved in a normal manner and did not photobleach, emphasizing the importance of the ligand design when it is necessary to have an optimum outcome: i.e., cell imaging or phototherapy applications.
000148502 536__ $$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2010-20500-C02-0
000148502 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148502 590__ $$a4.145$$b2012
000148502 591__ $$aCHEMISTRY, ORGANIC$$b11 / 57 = 0.193$$c2012$$dQ1$$eT1
000148502 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b6 / 44 = 0.136$$c2012$$dQ1$$eT1
000148502 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148502 700__ $$0(orcid)0000-0003-2548-0373$$aOrtego, M. Lourdes
000148502 700__ $$aWilliams,Cartin F.
000148502 700__ $$aCoogan, Michael P.
000148502 700__ $$0(orcid)0000-0002-3978-1145$$aVillacampa, M. Dolores$$uUniversidad de Zaragoza
000148502 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M. Concepción$$uUniversidad de Zaragoza
000148502 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000148502 773__ $$g31, 16 (2012), 5950-5957$$pOrganometallics$$tOrganometallics$$x0276-7333
000148502 8564_ $$s569443$$uhttps://zaguan.unizar.es/record/148502/files/texto_completo.pdf$$yPostprint
000148502 8564_ $$s713149$$uhttps://zaguan.unizar.es/record/148502/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148502 909CO $$ooai:zaguan.unizar.es:148502$$particulos$$pdriver
000148502 951__ $$a2025-01-17-14:37:01
000148502 980__ $$aARTICLE