Age differences in presentation, diagnosis pathway and management of colorectal cancer

Esteva, M. ; Ruiz, A. ; Ramos, M. ; Casamitjana, M. ; Sánchez-Calavera, M.A. (Universidad de Zaragoza) ; González-Luján, L. ; Pita-Fernández, S. ; Leiva, A. ; Pértega-Díaz, S. ; Costa-Alcaraz, A. ; Macià, F. ; Espí, A. ; Segura, J.M. ; Lafita, S. ; Novella, M.T. ; Yus, C. ; Oliván, B. ; Cabeza, E. ; Seoane-Pillado, T. ; López-Calviño, B. ; Llobera, J. ; Martín-Rabadán, M. Maria ; Teresa Novella, M. ; Ripoll, J. ; Manzano, H. ; Amengual, I. ; Forteza, A. ; Company, M. ; Lluch Bennassar, Maria de ; Sánchez, M.A. ; Magallón, R. ; Olivan, B. (Universidad de Zaragoza) ; Maciá, F. ; Pita, S. ; Pertega-Díaz, S. ; Louro, A. ; Serrano, J. ; Arnal, F. ; González-Santamaría, P. ; Seoane, T. ; González-Lujan, L. ; Costa-Alcaraz, A. ; Espí, I. ; Bosca, M.M. ; Balza, N. ; Villagrasa, R.A. ; Vázquez,J. F. ; González-Timoneda, Y.A.

Resumen: BACKGROUND: The gap in survival between older and younger European cancer patients is getting wider. It is possible that cancer in the elderly is being managed or treated differently than in their younger counterparts. This study aims to explore age disparities with respect to the clinical characteristics of the tumour, diagnostic pathway and treatment of colorectal cancer patients.
METHODS: We conducted a multicenter cross sectional study in 5 Spanish regions. Consecutive incident cases of CRC were identified from pathology services.
MEASUREMENTS: From patient interviews, hospital and primary care clinical records, we collected data on symptoms, stage, doctors investigations, time duration to diagnosis/treatment, quality of care and treatment.
RESULTS: 777 symptomatic cases, 154 were older than 80 years. Stage was similar by age group. General symptoms were more frequent in the eldest and abdominal symptoms in the youngest. No differences were found regarding perception of symptom seriousness and symptom disclosure between age groups as no longer duration to diagnosis or treatment was observed in the oldest groups. In primary care, only ultrasound is more frequently ordered in those <65 years. Those >80 years had a significantly higher proportion of iron testing and abdominal XR requested in hospital. We observed a high resection rate independently of age but less adjuvant chemotherapy in Stage III colon cancer, and of radiotherapy in stage II and III rectal cancer as age increases.
CONCLUSION: There are no relevant age disparities in the CRC diagnosis process with similar stage, duration to diagnosis, investigations and surgery. However, further improvements have to be made with respect to adjuvant therapy.

Idioma: Inglés

DOI: 10.1016/j.canep.2014.05.002

Año: 2014

Publicado en: Cancer Epidemiology 38, 4 (2014), 346-353
ISSN: 1877-7821

Factor impacto JCR: 2.711 (2014)

Categ. JCR: PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH rank: 38 / 164 = 0.232 (2014) - Q1 - T1
Categ. JCR: ONCOLOGY rank: 115 / 209 = 0.55 (2014) - Q3 - T2

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI050700
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI050787
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI052141
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI052273
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI052692
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RD06-0018
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-RETCI/RD12-0005-0011
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-RETCI/G03-170

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Psicología Social (Dpto. Psicología y Sociología)