000148544 001__ 148544
000148544 005__ 20250121144846.0
000148544 0247_ $$2doi$$a10.1002/jbm.b.34009
000148544 0248_ $$2sideral$$a104431
000148544 037__ $$aART-2018-104431
000148544 041__ $$aeng
000148544 100__ $$aGimeno, María
000148544 245__ $$aAntibiotic-eluting orthopedic device to prevent early implant associated infections: Efficacy, biocompatibility and biodistribution studies in an ovine model
000148544 260__ $$c2018
000148544 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148544 5203_ $$aInfection of orthopedic devices is a major complication in the postsurgical period generating important health issues and economic consequences. Prevention strategies could be based on local release of antibiotics from the orthopedic device itself to avoid adhesion and growth of bacteria. The purpose of this work is to demonstrate the efficiency to prevent these infections by a cefazolin-eluting, perforated stainless steel implant in an in vivo ovine model. The device was placed in the tibia of sheep, one group receiving cefazolin-loaded implants whereas the control group received empty implants. All implants were experimentally infected by direct inoculation of Staphylococcus aureus ATCC 6538. In vitro cytotoxicological studies were also performed to check the effect of antibiotic on cell viability, integrity, and cycle. Results showed that sheep receiving cefazolin-loaded devices were able to avoid implant-associated infections, with normal tissue healing process. The antibiotic release followed a local concentric pattern as demonstrated by high-performance liquid chromatography detection in tissues. The in vitro results indicate the lack of relevant cytotoxic effects for the maximum antibiotic concentration released by the device. These results demonstrate the efficiency and safety of cefazolin-eluting implants in an ovine model to prevent early postsurgical infections of orthopedic devices
000148544 536__ $$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
000148544 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148544 590__ $$a2.674$$b2018
000148544 591__ $$aENGINEERING, BIOMEDICAL$$b29 / 80 = 0.363$$c2018$$dQ2$$eT2
000148544 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b19 / 32 = 0.594$$c2018$$dQ3$$eT2
000148544 592__ $$a0.658$$b2018
000148544 593__ $$aBiomedical Engineering$$c2018$$dQ2
000148544 593__ $$aBiomaterials$$c2018$$dQ2
000148544 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148544 700__ $$0(orcid)0000-0002-9210-6026$$aPinczowski, Pedro
000148544 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000148544 700__ $$0(orcid)0000-0002-6178-4801$$aAsín, Javier$$uUniversidad de Zaragoza
000148544 700__ $$0(orcid)0000-0002-8712-2275$$aVázquez, Francisco J.$$uUniversidad de Zaragoza
000148544 700__ $$0(orcid)0000-0002-4921-4734$$aVispe, Eugenio
000148544 700__ $$0(orcid)0000-0003-2587-7506$$aGarcía-Álvarez, Felícito$$uUniversidad de Zaragoza
000148544 700__ $$0(orcid)0000-0002-8133-2124$$aPérez, Marta$$uUniversidad de Zaragoza
000148544 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, Jesús$$uUniversidad de Zaragoza
000148544 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000148544 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, Lluís$$uUniversidad de Zaragoza
000148544 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000148544 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000148544 7102_ $$11004$$2830$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Traumatología y Ortopedia
000148544 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000148544 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000148544 773__ $$g106 , 5 (2018), 1976-1986$$pJ. biomed. mater. res., Part B Appl. biomater.$$tJournal of Biomedical Materials Research - Part B Applied Biomaterials$$x1552-4973
000148544 8564_ $$s877103$$uhttps://zaguan.unizar.es/record/148544/files/texto_completo.pdf$$yPostprint
000148544 8564_ $$s1414480$$uhttps://zaguan.unizar.es/record/148544/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148544 909CO $$ooai:zaguan.unizar.es:148544$$particulos$$pdriver
000148544 951__ $$a2025-01-21-14:47:39
000148544 980__ $$aARTICLE