000148549 001__ 148549
000148549 005__ 20250120165541.0
000148549 0247_ $$2doi$$a10.1093/neuonc/not013
000148549 0248_ $$2sideral$$a116135
000148549 037__ $$aART-2013-116135
000148549 041__ $$aeng
000148549 100__ $$aGraus, F.
000148549 245__ $$aPatterns of care and outcome for patients with glioblastoma diagnosed during 2008-2010 in Spain
000148549 260__ $$c2013
000148549 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148549 5203_ $$aBackgroundTo assess management patterns and outcome in patients with glioblastoma multiforme (GBM) treated during 2008-2010 in Spain. MethodsRetrospective analysis of clinical, therapeutic, and survival data collected through filled questionnaires from patients with histologically confirmed GBM diagnosed in 19 Spanish hospitals.ResultsWe identified 834 patients (23% aged >70 years). Surgical resection was achieved in 66% of patients, although the extent of surgery was confirmed by postoperative MRI in only 41%. There were major postoperative complications in 14% of patients, and age was the only independent predictor (Odds ratio OR], 1.03; 95% confidence interval CI], 1.01-1.05; P =. 006). After surgery, 57% received radiotherapy (RT) with concomitant and adjuvant temozolomide, 21% received other regimens, and 22% were not further treated. In patients treated with surgical resection, RT, and chemotherapy (n = 396), initiation of RT =42 days was associated with longer progression-free survival (hazard ratio HR], 0.8; 95% CI, 0.64-0.99; P =. 042) but not with overall survival (HR, 0.79; 95% CI, 0.62-1.00; P =. 055). Only 32% of patients older than 70 years received RT with concomitant and adjuvant temozolomide. The median survival in this group was 10.8 months (95% CI, 6.8-14.9 months), compared with 17.0 months (95% CI, 15.5-18.4 months; P =. 034) among younger patients with GBM treated with the same regimen.ConclusionsIn a community setting, 57% of all patients with GBM and only 32% of older patients received RT with concomitant and adjuvant temozolomide. In patients with surgical resection who were eligible for chemoradiation, initiation of RT =42 days was associated with better progression-free survival.
000148549 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148549 590__ $$a5.286$$b2013
000148549 591__ $$aONCOLOGY$$b30 / 203 = 0.148$$c2013$$dQ1$$eT1
000148549 591__ $$aCLINICAL NEUROLOGY$$b18 / 191 = 0.094$$c2013$$dQ1$$eT1
000148549 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148549 700__ $$aBruna, J.
000148549 700__ $$aPardo, J.
000148549 700__ $$aEscudero, D.
000148549 700__ $$aVilas, D.
000148549 700__ $$aBarceló, I.
000148549 700__ $$aBrell, M.
000148549 700__ $$aPascual, C.
000148549 700__ $$aCrespo, J. A.
000148549 700__ $$aErro, E.
000148549 700__ $$aGarcía-Romero, J. C.
000148549 700__ $$aEstela, J.
000148549 700__ $$aMartino, J.
000148549 700__ $$aGarcía-Castaño, A.
000148549 700__ $$aMata, E.
000148549 700__ $$aLema, M.
000148549 700__ $$aGelabert, M.
000148549 700__ $$aFuentes, R.
000148549 700__ $$aPérez, P.
000148549 700__ $$aManzano, A.
000148549 700__ $$0(orcid)0000-0001-5821-3920$$aAguas, J.$$uUniversidad de Zaragoza
000148549 700__ $$aBelenguer, A.
000148549 700__ $$aSimón, A.
000148549 700__ $$aHenríquez, I.
000148549 700__ $$aMurcia, M.
000148549 700__ $$aVivanco, R.
000148549 700__ $$aRojas-Marcos, I.
000148549 700__ $$aMuñoz-Carmona, D.
000148549 700__ $$aNavas, I.
000148549 700__ $$aDe Andrés, P.
000148549 700__ $$aMas, G.
000148549 700__ $$aGil, M.
000148549 700__ $$aVerger, E.
000148549 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía
000148549 773__ $$g15, 6 (2013), 797-805$$pNeuro-oncology$$tNEURO-ONCOLOGY$$x1522-8517
000148549 8564_ $$s177568$$uhttps://zaguan.unizar.es/record/148549/files/texto_completo.pdf$$yVersión publicada
000148549 8564_ $$s2921316$$uhttps://zaguan.unizar.es/record/148549/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148549 909CO $$ooai:zaguan.unizar.es:148549$$particulos$$pdriver
000148549 951__ $$a2025-01-20-14:52:52
000148549 980__ $$aARTICLE