000148553 001__ 148553
000148553 005__ 20250127144949.0
000148553 0247_ $$2doi$$a10.1016/j.meegid.2020.104184
000148553 0248_ $$2sideral$$a116832
000148553 037__ $$aART-2020-116832
000148553 041__ $$aeng
000148553 100__ $$aComin, J.
000148553 245__ $$aInvestigation of a rapidly spreading tuberculosis outbreak using whole-genome sequencing
000148553 260__ $$c2020
000148553 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148553 5203_ $$aThis paper describes the application of whole-genome sequencing (WGS) to investigate an outbreak of Mycobacterium tuberculosis occurring in Aragon, Spain, where strains have been submitted to genotyping since 2004. The responsible outbreak strain appeared in our region first in 2014 and it spread to 14 patients in the following three years. WGS found low variability between the isolates with none of the SNPs differences detected more than once, all of which were attributed to a recent transmission. Although two ambiguous bases linked two cases with those who presented the SNP in the same position, the establishment of a definitive transmission route was not possible. The epidemiological data supported the existence of a super-spreader, probably responsible for the majority of the cases involved since there was a two-year delay in diagnoses among cases. This fact would also help explaining the low variability found. The index case was not identified, possibly because it was not diagnosed in Aragon. In addition WGS characterised the strain as a Linage 4.3.3/LAM family and corroborated the susceptibility to anti-tuberculosis drugs observed by the clinical laboratories. This work shows the need to have epidemiological data to support the genomic data in order to clarify the evolution of tuberculosis outbreaks.
000148553 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS15-0317$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS18-0336
000148553 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000148553 590__ $$a3.342$$b2020
000148553 591__ $$aINFECTIOUS DISEASES$$b51 / 92 = 0.554$$c2020$$dQ3$$eT2
000148553 592__ $$a1.085$$b2020
000148553 593__ $$aEcology, Evolution, Behavior and Systematics$$c2020$$dQ1
000148553 593__ $$aGenetics$$c2020$$dQ1
000148553 593__ $$aMolecular Biology$$c2020$$dQ1
000148553 593__ $$aMicrobiology$$c2020$$dQ1
000148553 593__ $$aMicrobiology (medical)$$c2020$$dQ1
000148553 593__ $$aInfectious Diseases$$c2020$$dQ1
000148553 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148553 700__ $$aChaure, A.
000148553 700__ $$0(orcid)0000-0002-3312-7759$$aCebollada, A.
000148553 700__ $$aIbarz, D.
000148553 700__ $$0(orcid)0000-0003-2044-6782$$aViñuelas, J.$$uUniversidad de Zaragoza
000148553 700__ $$0(orcid)0000-0003-4198-6622$$aVitoria, M. A.
000148553 700__ $$0(orcid)0000-0003-2266-8602$$aIglesias, M. J.$$uUniversidad de Zaragoza
000148553 700__ $$0(orcid)0000-0002-3011-2519$$aSamper, S.$$uUniversidad de Zaragoza
000148553 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000148553 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000148553 773__ $$g81 (2020), 104184 [7 pp.]$$pINFECTION GENETICS AND EVOLUTION$$tINFECTION GENETICS AND EVOLUTION$$x1567-1348
000148553 8564_ $$s701857$$uhttps://zaguan.unizar.es/record/148553/files/texto_completo.pdf$$yVersión publicada
000148553 8564_ $$s2385682$$uhttps://zaguan.unizar.es/record/148553/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148553 909CO $$ooai:zaguan.unizar.es:148553$$particulos$$pdriver
000148553 951__ $$a2025-01-27-14:45:29
000148553 980__ $$aARTICLE