000148555 001__ 148555
000148555 005__ 20250121144846.0
000148555 0247_ $$2doi$$a10.1016/j.mad.2020.111392
000148555 0248_ $$2sideral$$a121187
000148555 037__ $$aART-2021-121187
000148555 041__ $$aeng
000148555 100__ $$aCarmona-Pírez, J.
000148555 245__ $$aMultimorbidity networks of chronic obstructive pulmonary disease and heart failure in men and women: Evidence from the EpiChron Cohort
000148555 260__ $$c2021
000148555 5203_ $$aPatients with heart failure (HF) and/or chronic obstructive pulmonary disease (COPD) constitute a complex population with different phenotypes based on pathophysiology, comorbidity, sex and age. We aimed to compare the multimorbidity patterns of HF and COPD in men and women using network analysis. Individuals aged 40 years or older on 2015 of the EpiChron Cohort (Aragon, Spain) were stratified by sex and as having COPD (n = 28, 608), HF (n = 13, 414), or COPD and HF (n = 3952). We constructed one network per group by obtaining age-adjusted phi correlations between comorbidities. For each sex, networks differed between the three study groups; between sexes, similarities were found for the two HF groups. We detected some specific diseases highly connected in all networks (e.g., cardio-metabolic, respiratory diseases, and chronic kidney failure), and some others that were group-specific that would require further study. We identified common clusters (i.e., cardio-metabolic, cardiovascular, cancer, and neuro-psychiatric) and others specific and clinically relevant in COPD patients (e.g., behavioral risk disorders were systematically associated with psychiatric diseases in women and cancer in men). Network analysis represents a powerful tool to analyze, visualize, and compare the multimorbidity patterns of COPD and HF, also facilitated by developing an ad hoc website.
000148555 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B01-20R$$9info:eu-repo/grantAgreement/ES/IISA-ISCIII/CM19-00164
000148555 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148555 590__ $$a5.498$$b2021
000148555 591__ $$aGERIATRICS & GERONTOLOGY$$b18 / 54 = 0.333$$c2021$$dQ2$$eT2
000148555 591__ $$aCELL BIOLOGY$$b82 / 195 = 0.421$$c2021$$dQ2$$eT2
000148555 592__ $$a1.172$$b2021
000148555 593__ $$aDevelopmental Biology$$c2021$$dQ2
000148555 593__ $$aAging$$c2021$$dQ2
000148555 594__ $$a7.9$$b2021
000148555 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148555 700__ $$0(orcid)0000-0002-5119-5093$$aPoblador-Plou, B.
000148555 700__ $$0(orcid)0000-0002-3132-2171$$aDíez-Manglano, J.$$uUniversidad de Zaragoza
000148555 700__ $$aMorillo-Jiménez, M.J.
000148555 700__ $$0(orcid)0000-0001-9096-2294$$aMarín Trigo, J.M.$$uUniversidad de Zaragoza
000148555 700__ $$aIoakeim-Skoufa, I.
000148555 700__ $$0(orcid)0000-0002-5440-1710$$aGimeno-Miguel, A.
000148555 700__ $$aPrados-Torres, A.
000148555 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148555 773__ $$g193 (2021), 111392 [9 pp.]$$pMech. ageing dev.$$tMECHANISMS OF AGEING AND DEVELOPMENT$$x0047-6374
000148555 8564_ $$s4867827$$uhttps://zaguan.unizar.es/record/148555/files/texto_completo.pdf$$yVersión publicada
000148555 8564_ $$s2500818$$uhttps://zaguan.unizar.es/record/148555/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148555 909CO $$ooai:zaguan.unizar.es:148555$$particulos$$pdriver
000148555 951__ $$a2025-01-21-14:47:41
000148555 980__ $$aARTICLE