000148560 001__ 148560
000148560 005__ 20250120165542.0
000148560 0247_ $$2doi$$a10.1016/j.tube.2020.102022
000148560 0248_ $$2sideral$$a122388
000148560 037__ $$aART-2021-122388
000148560 041__ $$aeng
000148560 100__ $$aComín, J.
000148560 245__ $$aA whole-genome sequencing study of an X-family tuberculosis outbreak focus on transmission chain along 25 years
000148560 260__ $$c2021
000148560 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148560 5203_ $$aLineage 4/X-family of Mycobacterium tuberculosis is not very notorious, except for the CDC1551 strain. One strain of this family, named Ara50, caused one of the largest tuberculosis outbreaks of the Aragon region, Spain, during the 1990s and remained until 2018. These X-strains are characterised by high transmissibility and by carrying a low copy number of IS6110 in their genomes. Epidemiological data of the 61 patients consisted of inmates, HIV seropositives, intravenous drug users and the homeless. The application of whole-genome sequencing (WGS) to 36 out of 61 isolates, selected by IS6110-RFLP, allowed to confirm 32 as recent transmissions. We found 10 SNPs in genes considered as virulence factors, five of them specific of this strain. WGS identified three sub-clusters (CLSs). The largest one, sub-CLS 1, included 10 cases. Seven of them shared a SNP in the mce3C gene, considered a virulence factor gene. Sub-CLS 2 involved familiar cases, and no link was known for sub-CLS 3. Finally, the strain showed efficacy in latency as a confirmed epidemiological link was established between two cases, with 6 years of distance in their diagnosis. This outbreak study combined epidemiological and molecular analyses in order to elucidate tuberculosis transmission.
000148560 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS18-0336
000148560 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000148560 590__ $$a2.973$$b2021
000148560 591__ $$aMICROBIOLOGY$$b95 / 137 = 0.693$$c2021$$dQ3$$eT3
000148560 591__ $$aRESPIRATORY SYSTEM$$b46 / 66 = 0.697$$c2021$$dQ3$$eT3
000148560 591__ $$aIMMUNOLOGY$$b129 / 162 = 0.796$$c2021$$dQ4$$eT3
000148560 592__ $$a0.763$$b2021
000148560 593__ $$aImmunology$$c2021$$dQ2
000148560 593__ $$aMicrobiology$$c2021$$dQ2
000148560 593__ $$aInfectious Diseases$$c2021$$dQ2
000148560 594__ $$a5.3$$b2021
000148560 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion
000148560 700__ $$0(orcid)0000-0002-3312-7759$$aCebollada, A.
000148560 700__ $$aIbarz, D.
000148560 700__ $$0(orcid)0000-0003-2044-6782$$aViñuelas, J.$$uUniversidad de Zaragoza
000148560 700__ $$0(orcid)0000-0003-4198-6622$$aVitoria, M.A.
000148560 700__ $$0(orcid)0000-0003-2266-8602$$aIglesias, M.J.$$uUniversidad de Zaragoza
000148560 700__ $$0(orcid)0000-0002-3011-2519$$aSamper, S.$$uUniversidad de Zaragoza
000148560 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000148560 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000148560 773__ $$g126 (2021), 102022 [10 pp.]$$pTUBERCULOSIS$$tTUBERCULOSIS$$x1472-9792
000148560 8564_ $$s618310$$uhttps://zaguan.unizar.es/record/148560/files/texto_completo.pdf$$yPostprint
000148560 8564_ $$s1273077$$uhttps://zaguan.unizar.es/record/148560/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148560 909CO $$ooai:zaguan.unizar.es:148560$$particulos$$pdriver
000148560 951__ $$a2025-01-20-14:53:07
000148560 980__ $$aARTICLE