000148594 001__ 148594
000148594 005__ 20250120165542.0
000148594 0247_ $$2doi$$a10.1016/j.ijpharm.2013.04.076
000148594 0248_ $$2sideral$$a90778
000148594 037__ $$aART-2013-90778
000148594 041__ $$aeng
000148594 100__ $$aGimeno, Marina
000148594 245__ $$aPorous orthopedic steel implant as an antibiotic eluting device: prevention of post-surgical infection on an ovine model
000148594 260__ $$c2013
000148594 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148594 5203_ $$aTraumatology and orthopedic surgery can benefit from the use of efficient local antibiotic-eluting systems to avoid bacterial contamination of implanted materials. In this work a new percutaneous porous-wall hollow implant was successfully used as a local antibiotic-eluting device both in vitro and in vivo. The implant is a macroporous 316L stainless steel filter tube with a nominal filtration cut-off size of 200 nm with one open end which was used to load the synthetic antibiotic linezolid and an opposite blind end. The antibiotic release kinetics from the device on a simulated biological fluid under in vitro conditions demonstrated an increased concentration during the first five days that subsequently was sustained for at least seven days, showing a kinetic close to a zero order release. Antibiotic-loaded implants were placed in the tibia of four sheep which were trans-surgically experimentally infected with a biofilm forming strain of Staphylococcus aureus. After 7 and 9 days post infection, sheep did not show any evidence of infection as demonstrated by clinical, pathological and microbiological findings. These results demonstrate the capability of such an antibiotic-loaded implant to prevent infection in orthopedic devices in vivo. Further research is needed to assess its possible use in traumatology and orthopedic surgery.
000148594 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000148594 590__ $$a3.785$$b2013
000148594 591__ $$aPHARMACOLOGY & PHARMACY$$b45 / 255 = 0.176$$c2013$$dQ1$$eT1
000148594 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148594 700__ $$aPinczowski, Pedro
000148594 700__ $$0(orcid)0000-0002-8712-2275$$aVázquez, Francisco José$$uUniversidad de Zaragoza
000148594 700__ $$aPérez, Marta
000148594 700__ $$aSantamaría, Jesús
000148594 700__ $$aArruebo, Manuel
000148594 700__ $$aLuján, Lluis
000148594 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000148594 773__ $$g452, 16 (2013), 166-172$$pInt. j. pharm.$$tInternational Journal of Pharmaceutics$$x0378-5173
000148594 8564_ $$s4741101$$uhttps://zaguan.unizar.es/record/148594/files/texto_completo.pdf$$yPostprint
000148594 8564_ $$s1132324$$uhttps://zaguan.unizar.es/record/148594/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148594 909CO $$ooai:zaguan.unizar.es:148594$$particulos$$pdriver
000148594 951__ $$a2025-01-20-14:53:48
000148594 980__ $$aARTICLE