000148641 001__ 148641 000148641 005__ 20250120165542.0 000148641 0247_ $$2doi$$a10.1186/s40813-022-00252-3 000148641 0248_ $$2sideral$$a141781 000148641 037__ $$aART-2022-141781 000148641 041__ $$aeng 000148641 100__ $$aMartínez-Boixaderas, Núria 000148641 245__ $$aImpact of maternally derived immunity on immune responses elicited by piglet early vaccination against the most common pathogens involved in porcine respiratory disease complex 000148641 260__ $$c2022 000148641 5060_ $$aAccess copy available to the general public$$fUnrestricted 000148641 5203_ $$aAbstractNewborn piglets can trigger an elementary immune response, but the acquirement of specific antibodies and/or cellular immunity against pathogens before they get infected post-natally is paramount to preserve their health. This is especially important for the pathogens involved in porcine respiratory disease complex (PRDC) as they are widespread, fairly resistant at environment, and genetically variable; moreover, some of them can cause intrauterine/early life infections.Main bodyPiglet protection can be achieved by either passive transfer of maternal derived immunity (MDI) and/or actively through vaccination. However, vaccinating piglets in the presence of remaining MDI might interfere with vaccine efficacy. Hence, the purpose of this work is to critically review the putative interference that MDI may exert on vaccine efficacy against PRDC pathogens. This knowledge is crucial to design a proper vaccination schedule.ConclusionMDI transferred from sows to offspring could potentially interfere with the development of an active humoral immune response. However, no conclusive interference has been shown regarding performance parameters based on the existing published literature. 000148641 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000148641 590__ $$a3.4$$b2022 000148641 591__ $$aVETERINARY SCIENCES$$b10 / 144 = 0.069$$c2022$$dQ1$$eT1 000148641 592__ $$a0.763$$b2022 000148641 593__ $$aAnimal Science and Zoology$$c2022$$dQ1 000148641 593__ $$aSmall Animals$$c2022$$dQ1 000148641 593__ $$aFood Animals$$c2022$$dQ1 000148641 594__ $$a5.2$$b2022 000148641 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000148641 700__ $$0(orcid)0000-0001-7106-0068$$aGarza-Moreno, Laura$$uUniversidad de Zaragoza 000148641 700__ $$aSibila, Marina 000148641 700__ $$aSegalés, Joaquim 000148641 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal 000148641 773__ $$g8, 1 (2022), 12 pp.$$tPorcine Health Management$$x2055-5660 000148641 8564_ $$s1013642$$uhttps://zaguan.unizar.es/record/148641/files/texto_completo.pdf$$yVersión publicada 000148641 8564_ $$s2366335$$uhttps://zaguan.unizar.es/record/148641/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000148641 909CO $$ooai:zaguan.unizar.es:148641$$particulos$$pdriver 000148641 951__ $$a2025-01-20-14:54:42 000148641 980__ $$aARTICLE