000148646 001__ 148646
000148646 005__ 20250120165543.0
000148646 0247_ $$2doi$$a10.1172/jci.insight.181481
000148646 0248_ $$2sideral$$a141885
000148646 037__ $$aART-2024-141885
000148646 041__ $$aeng
000148646 100__ $$0(orcid)0000-0001-5573-6144$$aLayunta, Elena$$uUniversidad de Zaragoza
000148646 245__ $$aMUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease
000148646 260__ $$c2024
000148646 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148646 5203_ $$aCrohn's disease (CD) is the chronic inflammation of the terminal ileum and colon triggered by a dysregulated immune response to bacteria, but insights into specific molecular perturbations at the critical bacteria-epithelium interface are limited. Here we report that the membrane mucin MUC17 protected small intestinal enterocytes against commensal and pathogenic bacteria. In non-inflamed CD ileum, reduced MUC17 levels and a compromised glycocalyx barrier allowed recurrent bacterial contact with enterocytes. Muc17 deletion in mice rendered the small intestine particularly prone to atypical bacterial infection while maintaining resistance to colitis. The loss of Muc17 resulted in spontaneous deterioration of epithelial homeostasis and in the extra-intestinal translocation of bacteria. Finally, Muc17-deficient mice harbored specific small intestinal bacterial taxa observed in CD patients. Our findings highlight MUC17 as an essential regiospecific line of defense in the small intestine with relevance for early epithelial defects in CD.
000148646 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000148646 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148646 700__ $$aJäverfelt, Sofia
000148646 700__ $$avan de Koolwijk, Fleur C.
000148646 700__ $$aSivertsson, Molly
000148646 700__ $$aDolan, Brendan
000148646 700__ $$aArike, Liisa
000148646 700__ $$aThulin, Sara I.M.
000148646 700__ $$aVallance, Bruce A.
000148646 700__ $$aPelaseyed, Thaher
000148646 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000148646 773__ $$g(2024), [38 pp.]$$pJCI insight$$tJCI insight$$x2379-3708
000148646 8564_ $$s9492777$$uhttps://zaguan.unizar.es/record/148646/files/texto_completo.pdf$$yVersión publicada
000148646 8564_ $$s958016$$uhttps://zaguan.unizar.es/record/148646/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148646 909CO $$ooai:zaguan.unizar.es:148646$$particulos$$pdriver
000148646 951__ $$a2025-01-20-14:54:48
000148646 980__ $$aARTICLE