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000148683 001__ 148683 000148683 005__ 20250121150753.0 000148683 0248_ $$2sideral$$a99900 000148683 037__ $$aART-2015-99900 000148683 041__ $$aeng 000148683 100__ $$aLatorre, E. 000148683 245__ $$aListeria monocytogenes affects serotonin transporter activity and expression in human intestinal epithelial cells by TLR10 activation 000148683 260__ $$c2015 000148683 5203_ $$aIntroduction: Serotonin (5-HT) is a neuromodulator mainly synthesized in the intestinal epithelium. 5-HT regulates the whole intestinal physiology and it has been shown to be essential in intestinal homeostasis. In fact the excess of extracellular 5-HT has been described to contribute to intestinal inflammation. 5-HT availability is in part mediated by the serotonin transporter (SERT), which is responsible for the 5-HT reuptake inside the enterocytes. Recent results have demonstrated that bacteria resident in the intestinal lumen may affect intestinal pathophysiology by acting on the serotoninergic system. This effect is in part carried out through the activation of Toll-like receptors (TLRs) which regulates SERT in the intestinal epithelium. Listeria monocytogenes is a Gram-positive bacteria that causes in humans a serious infection (listeriosis) mainly through the consumption of ready-to-eat foods. Following ingestion, L. monocytogenes has been described to cross the intestinal epithelium and to invade intestinal epithelial cells. However, the effect of L. monocytogenes on intestinal epithelium activity remains unknown... 000148683 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000148683 590__ $$a2.933$$b2015 000148683 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b32 / 79 = 0.405$$c2015$$dQ2$$eT2 000148683 592__ $$a1.049$$b2015 000148683 593__ $$aOncology$$c2015$$dQ2 000148683 593__ $$aGastroenterology$$c2015$$dQ2 000148683 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000148683 700__ $$aPradilla, A. 000148683 700__ $$aChueca, B.$$uUniversidad de Zaragoza 000148683 700__ $$0(orcid)0000-0002-0238-6328$$aPagan, R.$$uUniversidad de Zaragoza 000148683 700__ $$0(orcid)0000-0001-5573-6144$$aLayunta, E.$$uUniversidad de Zaragoza 000148683 700__ $$0(orcid)0000-0003-4758-3998$$aMesonero, J.E.$$uUniversidad de Zaragoza 000148683 700__ $$aAlcalde, A.I. 000148683 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología 000148683 7102_ $$12008$$2780$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Tecnología de Alimentos 000148683 773__ $$g3, Suppl.1 (2015), P0564 [A311]$$pUnited European Gastroenterol. j.$$tUnited European Gastroenterology Journal$$x2050-6406 000148683 8564_ $$s119094$$uhttps://zaguan.unizar.es/record/148683/files/texto_completo.pdf$$yVersión publicada 000148683 8564_ $$s4366888$$uhttps://zaguan.unizar.es/record/148683/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000148683 909CO $$ooai:zaguan.unizar.es:148683$$particulos$$pdriver 000148683 951__ $$a2025-01-21-14:43:22 000148683 980__ $$aARTICLE
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