148683 20250121150753.0 sideral 99900 ART-2015-99900 eng Latorre, E. Listeria monocytogenes affects serotonin transporter activity and expression in human intestinal epithelial cells by TLR10 activation 2015 Introduction: Serotonin (5-HT) is a neuromodulator mainly synthesized in the intestinal epithelium. 5-HT regulates the whole intestinal physiology and it has been shown to be essential in intestinal homeostasis. In fact the excess of extracellular 5-HT has been described to contribute to intestinal inflammation. 5-HT availability is in part mediated by the serotonin transporter (SERT), which is responsible for the 5-HT reuptake inside the enterocytes. Recent results have demonstrated that bacteria resident in the intestinal lumen may affect intestinal pathophysiology by acting on the serotoninergic system. This effect is in part carried out through the activation of Toll-like receptors (TLRs) which regulates SERT in the intestinal epithelium. Listeria monocytogenes is a Gram-positive bacteria that causes in humans a serious infection (listeriosis) mainly through the consumption of ready-to-eat foods. Following ingestion, L. monocytogenes has been described to cross the intestinal epithelium and to invade intestinal epithelial cells. However, the effect of L. monocytogenes on intestinal epithelium activity remains unknown... info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.933 2015 GASTROENTEROLOGY & HEPATOLOGY 32 / 79 = 0.405 2015 Q2 T2 1.049 2015 Oncology 2015 Q2 Gastroenterology 2015 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pradilla, A. Chueca, B. Universidad de Zaragoza Pagan, R. Universidad de Zaragoza (orcid)0000-0002-0238-6328 Layunta, E. Universidad de Zaragoza (orcid)0000-0001-5573-6144 Mesonero, J.E. Universidad de Zaragoza (orcid)0000-0003-4758-3998 Alcalde, A.I. 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 2008 780 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Tecnología de Alimentos 3, Suppl.1 (2015), P0564 [A311] United European Gastroenterol. j. United European Gastroenterology Journal 2050-6406 119094 http://zaguan.unizar.es/record/148683/files/texto_completo.pdf Versión publicada 4366888 http://zaguan.unizar.es/record/148683/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:148683 articulos driver 2025-01-21-14:43:22 ARTICLE