000148711 001__ 148711
000148711 005__ 20250128150425.0
000148711 0247_ $$2doi$$a10.1159/000520179
000148711 0248_ $$2sideral$$a126657
000148711 037__ $$aART-2021-126657
000148711 041__ $$aeng
000148711 100__ $$aFabre, Marta
000148711 245__ $$aFrequent placental SARS-CoV-2 in patients with COVID-19-associated hypertensive disorders of pregnancy
000148711 260__ $$c2021
000148711 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148711 5203_ $$aIntroduction: Studies described an increased frequency of hypertensive disorders of pregnancy (HDP) after a COVID-19 episode. There is limited evidence about SARS-CoV-2 viral load in placenta. This study aimed to investigate the relationship between SARS-CoV-2 viral load in the placenta and clinical development of HDP after COVID-19 throughout different periods of gestation. Methods: This is a case-control study in women with and without gestational hypertensive disorders after SARS-CoV-2 infection diagnosed by RT-PCR during pregnancy. Patients were matched by gestational age at the moment of COVID-19 diagnosis. We performed an analysis of SARS-CoV-2 RNA levels in placenta. Results: A total of 28 women were enrolled. Sixteen patients were diagnosed with COVID-19 during the third trimester and the remaining 12 patients in the other trimesters. Ten placentas (35.7%) were positive for SARS-CoV-2, 9 of them (9/14, 64.3%) belonged to the HDP group versus 1 (1/14, 7.2%) in the control group (p = 0.009). Those cases with the highest loads of viral RNA developed severe preeclampsia (PE). Conclusion: Among women diagnosed with COVID-19 during pregnancy, the presence of SARS-CoV-2 in the placenta was more frequent among women suffering from PE or gestational hypertension. Furthermore, the most severe cases of HDP were associated with high placental viral load, not necessarily associated with a positive nasopharyngeal RT-PCR at delivery. Our data suggest that SARS-CoV-2 infection during pregnancy could trigger gestational hypertensive disorders through persistent placental infection and resulting placental damage. © 2021 S. Karger AG, Basel.
000148711 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B05-17D$$9info:eu-repo/grantAgreement/ES/ISCIII/CP21-00078$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/FI20/00071$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-02208$$9info:eu-repo/grantAgreement/ES/ISCIII/JR19-00006
000148711 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148711 590__ $$a2.208$$b2021
000148711 591__ $$aOBSTETRICS & GYNECOLOGY$$b66 / 85 = 0.776$$c2021$$dQ4$$eT3
000148711 592__ $$a0.935$$b2021
000148711 593__ $$aEmbryology$$c2021$$dQ1
000148711 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2021$$dQ1
000148711 593__ $$aPediatrics, Perinatology and Child Health$$c2021$$dQ1
000148711 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000148711 594__ $$a4.2$$b2021
000148711 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148711 700__ $$aCalvo, Pilar
000148711 700__ $$aRuiz-Martinez, Sara
000148711 700__ $$aPeran, María
000148711 700__ $$0(orcid)0000-0002-0670-5541$$aOros, Daniel
000148711 700__ $$aMedel-Martinez, Ana
000148711 700__ $$aStrunk, Mark
000148711 700__ $$0(orcid)0000-0001-5134-1006$$aBenito Ruesca, Rafael$$uUniversidad de Zaragoza
000148711 700__ $$aSchoorlemmer, Jon
000148711 700__ $$0(orcid)0000-0001-6795-0367$$aPaules, Cristina$$uUniversidad de Zaragoza
000148711 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000148711 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000148711 773__ $$g48, 11-12 (2021), 801–811$$pFetal diagn. ther.$$tFetal Diagnosis and Therapy$$x1015-3837
000148711 8564_ $$s891345$$uhttps://zaguan.unizar.es/record/148711/files/texto_completo.pdf$$yPostprint
000148711 8564_ $$s725513$$uhttps://zaguan.unizar.es/record/148711/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148711 909CO $$ooai:zaguan.unizar.es:148711$$particulos$$pdriver
000148711 951__ $$a2025-01-28-15:02:27
000148711 980__ $$aARTICLE