148711 20250128150425.0 doi 10.1159/000520179 sideral 126657 ART-2021-126657 eng Fabre, Marta Frequent placental SARS-CoV-2 in patients with COVID-19-associated hypertensive disorders of pregnancy 2021 Access copy available to the general public Unrestricted Introduction: Studies described an increased frequency of hypertensive disorders of pregnancy (HDP) after a COVID-19 episode. There is limited evidence about SARS-CoV-2 viral load in placenta. This study aimed to investigate the relationship between SARS-CoV-2 viral load in the placenta and clinical development of HDP after COVID-19 throughout different periods of gestation. Methods: This is a case-control study in women with and without gestational hypertensive disorders after SARS-CoV-2 infection diagnosed by RT-PCR during pregnancy. Patients were matched by gestational age at the moment of COVID-19 diagnosis. We performed an analysis of SARS-CoV-2 RNA levels in placenta. Results: A total of 28 women were enrolled. Sixteen patients were diagnosed with COVID-19 during the third trimester and the remaining 12 patients in the other trimesters. Ten placentas (35.7%) were positive for SARS-CoV-2, 9 of them (9/14, 64.3%) belonged to the HDP group versus 1 (1/14, 7.2%) in the control group (p = 0.009). Those cases with the highest loads of viral RNA developed severe preeclampsia (PE). Conclusion: Among women diagnosed with COVID-19 during pregnancy, the presence of SARS-CoV-2 in the placenta was more frequent among women suffering from PE or gestational hypertension. Furthermore, the most severe cases of HDP were associated with high placental viral load, not necessarily associated with a positive nasopharyngeal RT-PCR at delivery. Our data suggest that SARS-CoV-2 infection during pregnancy could trigger gestational hypertensive disorders through persistent placental infection and resulting placental damage. © 2021 S. Karger AG, Basel. info:eu-repo/grantAgreement/ES/DGA/B05-17D info:eu-repo/grantAgreement/ES/ISCIII/CP21-00078 info:eu-repo/grantAgreement/ES/ISCIII/FIS/FI20/00071 info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-02208 info:eu-repo/grantAgreement/ES/ISCIII/JR19-00006 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.208 2021 OBSTETRICS & GYNECOLOGY 66 / 85 = 0.776 2021 Q4 T3 0.935 2021 Embryology 2021 Q1 Radiology, Nuclear Medicine and Imaging 2021 Q1 Pediatrics, Perinatology and Child Health 2021 Q1 Medicine (miscellaneous) 2021 Q1 4.2 2021 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Calvo, Pilar Ruiz-Martinez, Sara Peran, María Oros, Daniel (orcid)0000-0002-0670-5541 Medel-Martinez, Ana Strunk, Mark Benito Ruesca, Rafael Universidad de Zaragoza (orcid)0000-0001-5134-1006 Schoorlemmer, Jon Paules, Cristina Universidad de Zaragoza (orcid)0000-0001-6795-0367 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1013 645 Universidad de Zaragoza Dpto. Cirugía Área Obstetricia y Ginecología 48, 11-12 (2021), 801–811 Fetal diagn. ther. Fetal Diagnosis and Therapy 1015-3837 891345 http://zaguan.unizar.es/record/148711/files/texto_completo.pdf Postprint 725513 http://zaguan.unizar.es/record/148711/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:148711 articulos driver 2025-01-28-15:02:27 ARTICLE