000148724 001__ 148724
000148724 005__ 20250121150753.0
000148724 0247_ $$2doi$$a10.1016/j.indcrop.2021.114413
000148724 0248_ $$2sideral$$a128227
000148724 037__ $$aART-2022-128227
000148724 041__ $$aeng
000148724 100__ $$aSanchez-Gomez, Susana
000148724 245__ $$aLethal and sublethal effects of essential oil-loaded zein nanocapsules on a zoonotic disease vector mosquito, and their non-target impact
000148724 260__ $$c2022
000148724 5203_ $$aRecently the agrochemical industry is developing eco-friendly approaches based on the fabrication of biopesticides using substances, including biomass-borne products, with limited impact on human health and environment. One of these is the use of vegetable proteins, such as the corn-derived zein, as a safe nanocarrier loaded with bioactive compounds. Zein-based nanoparticles have been successfully applied to enhance the antimicrobial, antioxidant, repellent and insecticidal properties of hydrophobic substances such as essential oils (EOs). Herein, we developed two EO-loaded zein nanocapsules (NC) for mosquito larvicidal purposes. As active ingredients, we selected two Apiaceae essential oils (EO) with well documented insecticidal activities, i.e. Pimpinella anisum and Trachyspermum ammi, containing (E)-anethole and thymol as main constituents, respectively. The EO-based zein NC were prepared by self-assembly without using organic solvents, characterized for particle size by dynamic light scattering (DLS) and for stability over time and throughout stress conditions. EOloaded zein NC showed high acute toxicity on Culex quinquefasciatus 3rd instar larvae. Sublethal toxicity following 1-5 h to the LC90 was noted in terms of larval and pupal mortality, emerged adult rate, and sex ratio. The NC ecotoxicological safety was demonstrated, showing limited non-target effects on aquatic (Daphnia magna) and terrestrial (Eisenia fetida) invertebrates, as also on vertebrate cells (human keratinocytes). Overall, the P. anisum and T. ammi EO-loaded zein NC may represent effective and eco-friendly formulations to be considered in mosquito control programs, pending field evaluation of their epidemiological impact.
000148724 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/PGC2018-093789-B-I00
000148724 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148724 590__ $$a5.9$$b2022
000148724 591__ $$aAGRONOMY$$b7 / 88 = 0.08$$c2022$$dQ1$$eT1
000148724 591__ $$aAGRICULTURAL ENGINEERING$$b3 / 14 = 0.214$$c2022$$dQ1$$eT1
000148724 592__ $$a0.897$$b2022
000148724 593__ $$aAgronomy and Crop Science$$c2022$$dQ1
000148724 594__ $$a9.7$$b2022
000148724 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148724 700__ $$0(orcid)0000-0002-0238-6328$$aPagan, Rafael$$uUniversidad de Zaragoza
000148724 700__ $$aPavela, Roman
000148724 700__ $$aMazzara, Eugenia
000148724 700__ $$aSpinozzi, Eleonora
000148724 700__ $$aMarinelli, Oliviero
000148724 700__ $$aZeppa, Laura
000148724 700__ $$aMorshedloo, Mohammad Reza
000148724 700__ $$aMaggi, Filippo
000148724 700__ $$aCanale, Angelo
000148724 700__ $$aBenelli, Giovanni
000148724 7102_ $$12008$$2780$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Tecnología de Alimentos
000148724 773__ $$g176 (2022), 114413 - [9 pp]$$pInd. crops prod.$$tINDUSTRIAL CROPS AND PRODUCTS$$x0926-6690
000148724 8564_ $$s993888$$uhttps://zaguan.unizar.es/record/148724/files/texto_completo.pdf$$yVersión publicada
000148724 8564_ $$s2415280$$uhttps://zaguan.unizar.es/record/148724/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148724 909CO $$ooai:zaguan.unizar.es:148724$$particulos$$pdriver
000148724 951__ $$a2025-01-21-14:44:12
000148724 980__ $$aARTICLE