000148768 001__ 148768
000148768 005__ 20250121150754.0
000148768 0247_ $$2doi$$a10.1016/j.parint.2025.103028
000148768 0248_ $$2sideral$$a142044
000148768 037__ $$aART-2025-142044
000148768 041__ $$aeng
000148768 100__ $$aBeltrán-Rosel, Antonio$$uUniversidad de Zaragoza
000148768 245__ $$aFalciparum malaria in a child from Ghana with neutrophils showing phagocytosis of trophozoites, merozoites and possibly schizont
000148768 260__ $$c2025
000148768 5203_ $$aMalaria remains a significant health threat in tropical and subtropical regions. The immune response to Plasmodium falciparum involves both humoral and cellular components, including phagocytosis by neutrophils. However, observing phagocytosis through light microscopy is uncommon. This report presents a rare case of falciparum malaria in a Ghanaian twin, highlighting intracellular P. falciparum forms in neutrophils. Two 7-year-old male twins from Ghana were admitted with fever, vomiting, and abdominal pain. They tested positive for P. falciparum infection via rapid diagnostic tests and blood smears. Child 1 displayed significant neutrophilia and intracellular parasites, including trophozoites, merozoites, and a potential schizont, within neutrophils. Child 2 showed no phagocytosis but exhibited other signs of systemic inflammation and hemolysis. Both children were treated successfully with piperaquine tetraphosphate/artenimol (Eurartesim®). This case provides rare microscopic evidence of P. falciparum phagocytosis by neutrophils, suggesting prior antibody development in the patient. While the findings highlight the role of phagocytosis in parasite clearance, the absence of similar observations in the second twin raises questions about individual immune responses and genetic factors. Further research is needed to explore the underlying biological mechanisms.
000148768 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148768 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148768 700__ $$aLigero-López, Jorge$$uUniversidad de Zaragoza
000148768 700__ $$aLópez-Alonso, Beatriz
000148768 700__ $$aBoquera-Albert, Amparo
000148768 700__ $$aFerreira-Ferreira, Ingrid
000148768 700__ $$0(orcid)0000-0001-8346-0544$$aCollado-Hernández, Pilar$$uUniversidad de Zaragoza
000148768 700__ $$aRubio-Muñoz, José Miguel
000148768 7102_ $$11011$$2660$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Parasitología
000148768 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000148768 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000148768 773__ $$g106 (2025), 103028 [3 pp.]$$pPARASITOL INT$$tPARASITOLOGY INTERNATIONAL$$x1383-5769
000148768 8564_ $$s759374$$uhttps://zaguan.unizar.es/record/148768/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-01-03
000148768 8564_ $$s2370207$$uhttps://zaguan.unizar.es/record/148768/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-01-03
000148768 909CO $$ooai:zaguan.unizar.es:148768$$particulos$$pdriver
000148768 951__ $$a2025-01-21-14:45:11
000148768 980__ $$aARTICLE