000148770 001__ 148770
000148770 005__ 20260217205541.0
000148770 0247_ $$2doi$$a10.1155/ane/4714514
000148770 0248_ $$2sideral$$a142021
000148770 037__ $$aART-2024-142021
000148770 041__ $$aeng
000148770 100__ $$aDíaz-Insa, Samuel
000148770 245__ $$aBurden of Episodic and Chronic Migraine in Patients Who Had Failed Multiple Preventive Treatments From France, Spain, and the United Kingdom
000148770 260__ $$c2024
000148770 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148770 5203_ $$aObjectives: Migraine affects more than 80 million people in Western Europe. The present study evaluated disability and health‐related quality of life (HRQoL) among patients with episodic migraine (EM) and chronic migraine (CM) who had failed multiple preventive treatments.Materials and Methods: This study was an analysis of cross‐sectional, web‐based survey data from adult patients with migraine (EM and CM) from the United Kingdom, France, and Spain who had self‐reported failure of two or more preventive treatments. Patient characteristics and patient‐reported HRQoL, migraine‐related disability, healthcare resource use (HCRU), and burden of migraine were evaluated by classification (CM and EM) and country (EM only).Results: In this sample of 316 patients (United Kingdom, n = 106; Spain, n = 105; France, n = 105), 76 (24.1%) patients had CM, the mean (standard deviation [SD]) age was 39.5 (12.3) years, and 164 (51.9%) patients were female. Those patients with CM reported greater migraine‐related disability based on Migraine Disability Assessment (MIDAS) scores versus those with EM (mean [SD]: 43.8 [44.7] vs. 23.2 [28.3]), as well as greater pain‐related impact on daily activities and higher HCRU. Among patients with EM, MIDAS scores indicated disability was severe in Spain (mean [SD]: 31.6 [31.1]) and France (24.3 [31.1]) and moderate in the United Kingdom (13.8 [17.9]), while HRQoL was similar across countries. Regarding the burden of EM, higher levels of pain and symptom‐related interference with many aspects of life, including occupational functioning, were reported in the United Kingdom and Spain versus France.Conclusions: Migraine is associated with substantial disability and decreased HRQoL among patients who have failed previous preventive therapies. Although migraine burden varied by country, the results suggest high unmet needs in all countries. Appropriate treatment could reduce migraine‐related burden and HCRU among patients with difficult‐to‐treat migraine.
000148770 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000148770 590__ $$a2.7$$b2024
000148770 592__ $$a0.947$$b2024
000148770 591__ $$aCLINICAL NEUROLOGY$$b129 / 286 = 0.451$$c2024$$dQ2$$eT2
000148770 593__ $$aMedicine (miscellaneous)$$c2024$$dQ1
000148770 593__ $$aNeurology (clinical)$$c2024$$dQ2
000148770 593__ $$aNeurology$$c2024$$dQ2
000148770 594__ $$a7.2$$b2024
000148770 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148770 700__ $$0(orcid)0000-0001-5139-6031$$aSantos-Lasaosa, Sonia$$uUniversidad de Zaragoza
000148770 700__ $$aDriessen, Maurice T.
000148770 700__ $$aCohen, Joshua M.
000148770 700__ $$aLee, Lulu
000148770 700__ $$aGoadsby, Peter J.
000148770 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148770 773__ $$g2024, 1 (2024), [16 pp.]$$pActa neurol. Scand.$$tACTA NEUROLOGICA SCANDINAVICA$$x0001-6314
000148770 8564_ $$s1194538$$uhttps://zaguan.unizar.es/record/148770/files/texto_completo.pdf$$yVersión publicada
000148770 8564_ $$s2181052$$uhttps://zaguan.unizar.es/record/148770/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148770 909CO $$ooai:zaguan.unizar.es:148770$$particulos$$pdriver
000148770 951__ $$a2026-02-17-20:36:21
000148770 980__ $$aARTICLE